Serotonin and serotonergic neurotransmitter system

<p>From: Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia
Serotonin is much more than just a neurotransmitter that regulates mood. It could be called one of the &ldquo;master commanders&rdquo; of the body, as it plays a role in a wide variety of biological functions.</p>

<p>From:&nbsp;<a href="https://www.ncbi.nlm.nih.gov/pubmed/15570154">Reduction of serotonin transporters of patients with chronic fatigue syndrome. - PubMed - NCBI</a></p>

<p>To assess the involvement of serotonin in the symptoms of chronic fatigue syndrome, we investigated the serotonergic neurotransmitter system of chronic fatigue syndrome patients by the positron emission tomography (PET). Here we show that the density of serotonin transporters (5-HTTs) in the brain, as determined by using a radiotracer, CMcN5652, was significantly reduced in the rostral subdivision of the anterior cingulate as compared with that in normal volunteers. This subdivision is different from that in the dorsal anterior cingulate in which binding potential values of individual patient showed a weak negative correlation with self-reported pain score of the patients. Therefore, an alteration of serotonergic system in the rostral anterior cingulate plays a key role in pathophysiology of chronic fatigue syndrome.</p>