Systemic Exertion Intolerance
<p>From: <a id="null" class="null" href="http://jpet.aspetjournals.org/content/jpet/early/2018/08/03/jpet.118.250845.full.pdf">http://jpet.aspetjournals.org/content/jpet/early/2018/08/03/jpet.118.250845.full.pdf</a></p>
<p>If found then leads to a switch to anaerobic glycolysis</p>
<p>Apparently, systemic exertion intolerance in repeated cardio-pulmonary exercise tests was demonstrated in ME/CFS patients present as compared to healthy controls suggesting insufficient metabolic adaptation to incremental exercise (Vermeulen and Vermeulen, I, 2014), (Keller, et al., 2014). It should be noted, that the Vermeulen and Vermeulen study including controls, which were not matched to ME/CFS in terms of fitness, while the Keller et al study had no controls. McCully et al This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on August 3, 2018 as DOI: 10.1124/jpet.118.250845 at ASPET Journals on August 25, 2018 jpet.aspetjournals.org Downloaded from JPET #250845 9 published a number of papers showing that when matched for aerobic fitness, cardiorespiratory responses to exercise in patients with ME/CFS only and ME/CFS plus FM were not different from those in sedentary healthy controls (Cook, et al., 2006)</p>