Damage to Pituitary gland could decrease response to CRH (or decrease in triggering the release of hormone adrenocorticotropin (ACTH) into the bloodstream)

<p>From: <a href="https://www.ncbi.nlm.nih.gov/pubmed/9669518">Blunted adrenocorticotropin and cortisol responses to corticotropin-releasing hormone stimulation in chronic fatigue syndrome. - PubMed - NCBI</a></p>

<p>The blunted response of ACTH to exogenous CRH stimulation may be due to an abnormality in CRH levels with a resultant alteration in pituitary CRH receptor sensitivity or it may reflect a dysregulation of vasopressin or other factors involved in HPA regulation.</p>