report on stroke rehab
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+1b Regions Affected by Head Injury (Possible)
Neurosteroidal Systems
Acting as "Micro-Hormones" fine tuning “Macro-Hormones” activity in brain
Hormones (detailed)
1 pTBI-CF, TBI
1 Regions
Damage to Frontal cortex and synapses
Hyper State Lower Function
Parents
2 Effects and Systems Effects
Damage to Frontal cortex and synapses
reduced levels of ATP or ATP production
Children
9 Hypometabolic state (as evident in plasma and serum metabolomics)
Circulatory
Cognition
Hypervigilance
Low Level Inflamation (on-going state of low level over-activity)
Stress Response 1
Stress Response 2
Sustained Arousal
Jumps
+5b Reduction in the capacity with which HPA axis hormones can restrain the immune system
16 Reduced concentrations of amino acids that maintain TCA cycle capacity (suggesting) impaired fuelling of the TCA cycle by pyruvate
8 Chronic Immune Activation
increased utilization of acetyl-CoA-producing amino acids as alternative substrates for fuelling aerobic metabolism via the TCA cycle
Normally, cortisol also exerts a feedback effect to shut down the stress response after the threat has passed, acting upon the hypothalamus and causing it to stop producing CRH
Relatively Minor Physical or Psychological Stressors May Be Transduced into an Inflammatory Response by Triggering the Release of Inflammasomes and Subsequently Proinflammatory Cytokines
The stress circuit