NADH

From discussion 'Anyone Tried NADH for Energy?' on <a href="http://forums.phoenixrising.me/index.php?threads/anyone-tried-nadh-for-energy.4068/page-2">http://forums.phoenixrising.me/index.php?threads/anyone-tried-nadh-for-energy.4068/page-2</a>

NADH - An Essential Coenzyme

NADH is a naturally occurring coenzyme that is necessary for the production of energy in each of our 100 trillion cells. Found in the highest concentrations in the cell's mitochondria, this essential nutrient and potent antioxidant facilitates the production of cellular energy in the form of adenosine triphosphate (ATP) – and plays a role in thousands of chemical reactions that occur in the body. Without NADH, energy production is severely impaired.

Dr. Lapp recommended NADH for me. It was something that he had found helped most people. I started B-12 injections and became more focused on pacing at the same time, so I can't say for sure that it helped, but I definitely felt better. I think it's worth a try.

Also, he said it stops being helpful after a while and had me stop it periodically to see if it made a difference.

NADH is one of the few supplements that has worked consistently for me. It improves my energy levels only slightly, but really helps my cognitive skills. I take a 10 mg sublingual in the morning before eating.

VERY IMPORTANT that you must take them on an empty stomach with water about an hour before food , as it will only work if the pills pass through the stomach and dissolve in your intestine. Waste of time if they dissolve in the stomach. Hope that helps

They worked wonders for me in improving energy levels, and managed to get back to part time work, But i over worked trying to get my life back in order and i relapsed back, now been kept on the lowest level of benefit for the last four years and cannot afford them. But i would recommend them two anyone with problems with lack of energy.

I noticed an immediate increase in cognitive clarity and energy when I started 10 mg NADH. Over time the effect lessened, but I've continued taking it for several years because my energy level drops if I quit.

I take it on an empty stomach in the a.m, 1/2 hr before eating. (Perhaps an hour beore eating would be better, not sure.)

http://www.iherb.com/Co-E1-mojo-Plus-Enada-20-mg-30-Tablets/9292?at=0

I have used this brand 20mg sublingual tablets which are dissolved under your tongue, no need to worry about taking before food etc as its absorbed straight into the system . I found it had some good effects on energy but mainly cognitive energy, nothing out of the box but still worth it. I found it no more effective taking it regularly versus on a as needs basis. Gave me a 4-6hr lift. When in a crash though nothing works though, lol.

I suggest try it and see how u go.

I've had good and bad effects from NADH, too. I think it can be a double-edged sword metabolically, like Co Q-10 and how Dr. Cheney doesn't recommend Co Q-10 anymore. Even though it can increase cell energy metabolism, if the other cell structures can't handle it, I think maybe it could overload them and cause more trouble. I noticed the last time I took NADH after developing immune CFS last year that it made my heart function noticeably weaken, like CHF symptoms. It took a couple days off the NADH to bounce back. I don't know whether that's a cell energy thing or a neurotransmitter or related thing, but at the time I suspected cell energy because of how it took a few days to recover. Otoh, I also had some bad ADD from NADH before that, so it's possible it's transmitter related or something else entirely. It's interesting to me that that study someone posted cited lowered heart rate and lowered anxiety effects from it.

I read about NADH a long time ago, in a placebo controlled study of CFS sufferers who reported good results from using it. I tried it and have been using it for years. I take the 10mg tab, usually, but the last time I bought it, the sublingual was on sale, much cheaper, so I bought that instead. I had been keeping a few sublinguals to take before physical activity, such as walking, in addition to my usual morning dose. I'm finding this easier to use, but I'm thinking maybe the other way was more effective...not sure.

The original directions for use said to take the tab at least 20 minutes before eating and, if possible, be active or at least standing up, for that 20 minutes, to get it to circulate and get to the muscles, which was what the study was about....physical energy levels. I'd never heard of it being used to change heart rate or treat anxiety. The study also said improvements continued for at least 6 weeks before leveling off somewhat and then continued to rise slightly for another 5-6 months.

NADH, a type of B Vitamin, a coenzyme that the original study said some bodies don't create out of the B3/Niacin in their diet or supplements. It is important in the production of ATP, cell energy, from glucose in the liver.

According to Wikipedia a Niacin deficiency can lead to:"Common psychiatric symptoms of niacin deficiency include irritability, poor concentration, anxiety, fatigue, restlessness, apathy, and depression. Mild niacin deficiency has been shown to slow metabolism, leading to cold intolerance."

NADH is the only thing I have found that helps me with energy. There is more info here: http://www.nadh.com/

I also buy mine online there...good supportive people and money back guarantee.

I also have very good results in cognitive improvement with the NADH 10 mg sublingual taken in the morning before I eat.

To save money I buy the 20 mg and take a half one each morning. Buying 4 packs at time brings me to a little over $11 a month which is well worth it. One of the best things I use.

<a href="http://www.iherb.com/Co-E1-mojo-Plus-Enada-20-mg-30-Tablets/9292?at=0">http://www.iherb.com/Co-E1-mojo-Plus-Enada-20-mg-30-Tablets/9292?at=0</a>

10 mg twice a day is a LOT. For me at least. I take about 3mg when I take it. Or less.

I took NADH along with CoQ and Sam-E and felt very wired, almost too energetic. I recently came across this article that links NADH depletion to Cytopathic hypoxia (deficient cellular respiration), lowering ATP and energy production. A low NADH state was caused by proinflammatory cytokines, oxidative stress. Maybe this is one of the mechanisms of CFS.

http://ccforum.com/content/cc1824

NADH is really helpful for me, but not if I take it all the time. I take 5 mg (1/2 tab) daily, but if I'm going to have a big day I double that. But I do so with caution: while I often feel really good, maybe even great, on those rare days 10 mg days, I have to be careful to not over-do activity or I'll have a huge crash. To achieve something like Christmas day with extending family (which includes a 90 min. drive each way), I'll take 10 mg the day before, day of, and day after, but again if my over-all activity level has been too much I'll have a huge crash lasting for weeks. I have to be conscious of simply enjoying the day more, not doing more than I would without taking it. Those good days tempt me to take it at the higher dose all the time but if I do it will stop working and then I won't have that helpful boost when I need it. I've been reading up on this lately and if you search at PubMed you'll find one study of NADH with CFS that was for 48 months, and many people felt quite a bit better in ll symptoms for the first third of the study but then got worse. I've read other things about pulsing the dose, taking a week off every month, and I tried that for a while, but for me this 5 mg daily/10 mg for big days works best. It is sad to find something that can provoke a good day but to learn, over time, that it's temporary. The first few times this happened I was so hopeful I'd turned a corner, started looking into travel and grad school, but neither were to be. Since then, a good day here and there is still great, and I'd be glad if this proves helpful for anyone else.