oxidative stress and a decrease in antioxidant capacity in addition to the presence of histone deacetylase (HDAC)

<p>From:&nbsp;<a href="https://www.hindawi.com/journals/isrn/2013/784520/">A Review of Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome</a></p>

<p>Another potential cause of disruption to HPA axis function is oxidative stress and a decrease in antioxidant capacity in addition to the presence of histone deacetylase (HDAC) [<a href="https://www.hindawi.com/journals/isrn/2013/784520/#B40">72</a>]. Increased activity of HDAC 2 and 3 coincides with a decrease in plasma cortisol [<a href="https://www.hindawi.com/journals/isrn/2013/784520/#B14">14</a>]. This theory has been cited as another possible cause of hypocortisolism found in patients.</p>