ACTH

From: <a href="https://www.ncbi.nlm.nih.gov/pubmed/9669518">Blunted adrenocorticotropin and cortisol responses to corticotropin-releasing hormone stimulation in chronic fatigue syndrome. - PubMed - NCBI</a>

A diminished output of neurotrophic ACTH, causing a reduced adrenocortical secretory reserve, inadequately compensated for by adrenoceptor upregulation, may explain the reduced cortisol production demonstrated in this study.

From: Traumatic Brain Injury, Panhypopituitarism and Hormonal Evaluations as a Standard of Care
<a href="http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf">http://www.nevadaosteopathic.org/attachments/article/33/Clearfield%20Panhypopituitarism%20and%20TBI.pdf</a><img src="/c176f6c5-292d-55c1-b96c-aff56799a638.png" />

From: <a href="https://www.prohealth.com/library/acetylcholine-mediated-vasodilatation-in-the-microcirculation-of-patients-with-chronic-fatigue-syndrome-21916">Acetylcholine Mediated Vasodilatation in the Microcirculation of Patients with Chronic Fatigue Syndrome - Prohealth</a>

Apart from its neurotransmitter functions, acetylcholine is, of course, a well-established and prominent vasodilator whose action is dependent upon an intact layer of functioning endothelial cells that line the lumen of all blood vessels. This mini-review brings together a number of novel studies, examining blood vessel endothelial biology in CFS/ME patients, which have now been published by the research group at the University of Dundee, UK. This group has found clear abnormalities associated with a specific endothelium-dependent vasodilator — acetylcholine — and the review sets out to explain the biology and significance of the acetylcholine pathway as it affects endothelial cells, and what experiments are needed to unravel the mystery of the sensitivity seen in CFS/ME patients. The review is divided into 5 sections and a conclusion, and an overview of each is given in brief below.

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