11 Endocannabinoids

<p>From:&nbsp;<a href="http://fblt.cz/en/skripta/regulacni-mechanismy-2-nervova-regulace/5-neurotransmisni-systemy/">4. Neurotransmitter Systems&nbsp;&bull; Functions of Cells and Human Body</a>
Endocannabinoids</p>

<p>Their main representative is anandamide (arachidonoylethanolamide, AEA) &ndash; amide of ethanolamine and arachidonic acid.<strong>&nbsp;</strong>The synthesis and degradation is complex and can be found in the literature.</p>

<p>Anandamide acts in the CNS and immune system via cannabinoid receptors:</p>

<p><strong>1) CB1 receptors</strong></p>

<p>Present mostly in the CNS presynaptically on GABAergic neurons they are coupled to a G-protein. Their activation inhibits the release of GABA into the synapse. This phenomenon is called depolarisation-induced inhibition suppression.</p>

<p>CB1 receptor agonists have orexigenic effects and stimulate the reward system.</p>

<p><strong>2) CB2 receptors</strong></p>

<p>Mostly present in the peripheral nervous system, hematopoietic and immune cells. They play a role in pain relief and immune response.</p>