Fluoride poisoning
<p>In high concentrations, soluble <a href="http://en.wikipedia.org/wiki/Fluoride" title="Fluoride" >fluoride</a> <a href="http://en.wikipedia.org/wiki/Salts" title="Salts" class="mw-redirect" >salts</a> are <a href="http://en.wikipedia.org/wiki/Toxic" title="Toxic" class="mw-redirect" >toxic</a> and skin or eye contact with high concentrations of many fluoride salts is dangerous. Referring to a common salt of fluoride, <a href="http://en.wikipedia.org/wiki/Sodium_fluoride" title="Sodium fluoride" >sodium fluoride</a> (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg/kg elemental fluoride/kg body weight)</p>
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.<sup id="cite_ref-0" class="reference" ><a href="http://en.wikipedia.org/wiki/Fluoride_poisoning#cite_note-0" >[1]</a></sup><sup id="cite_ref-1" class="reference" ><a href="http://en.wikipedia.org/wiki/Fluoride_poisoning#cite_note-1" >[2]</a></sup><sup id="cite_ref-2" class="reference" ><a href="http://en.wikipedia.org/wiki/Fluoride_poisoning#cite_note-2" >[3]</a></sup> Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.2–0.3 mg/kg) than lethal doses.<sup id="cite_ref-Gessner94_3-0" class="reference" ><a href="http://en.wikipedia.org/wiki/Fluoride_poisoning#cite_note-Gessner94-3" >[4]</a></sup> Although helpful for dental health in low dosage, chronic exposure to fluoride in large amounts interferes with bone formation. In this way, the greatest examples of fluoride poisoning arises from fluoride-rich ground water.<sup id="cite_ref-Pearce_4-0" class="reference" ><a href="http://en.wikipedia.org/wiki/Fluoride_poisoning#cite_note-Pearce-4" >[5]</a></sup></p>