GPR119

G protein-coupled receptor 119 also known as GPR119 is a G protein-coupled receptor that in humans is encoded by the GPR119gene.^[1]

GPR119, along with GPR55 and GPR18, have been implicated as novel cannabinoid receptors.^[2][3][4]

GPR119 is expressed predominantly in the pancreas and  gastrointestinal tract 

in rodents and humans, as well as in the brain in rodents.^[5]

Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats.^[5] GPR119 has also been shown to regulate incretin and insulin hormone secretion.^[6][7][8]

As a result, new drugs acting on the receptor have been suggested as novel treatments for obesity and diabetes.^[5][7][9]