Cold Agglutinin Disease

<p>The <b>I and i determinants</b> are carbohydrate structures on lipids integral to red cells, and are also present on proteins in the plasma. The<b> I antigen</b>, found primarily on adult red cells, is located on branched chains, while the <b>i antigen</b>, found primarily on cord/infant red cells, is found on unbranched chains.</p>