Neuroblastoma,Clinical Presentation

<p>Signs and symptoms of neuroblastoma may include:

Asymptomatic

Abdominal mass (retroperitoneal or hepatic)

Abdominal pain or constipation

Proptosis

Periorbital ecchymoses ("raccoon eyes", from periorbital ecchymosis caused by orbital metastases)

Horner syndrome (miosis, ptosis, anhidrosis)

Localized back pain, weakness (from spinal cord compression)

Scoliosis, bladder dysfunction

Palpable nontender subcutaneous nodules

Opsoclonus myoclonus ataxia syndrome

Otherwise unexplained secretory diarrhea (from paraneoplastic production of vasoactive intestinal polypeptide [VIP])

Systemic symptoms (fever, weight loss)

Bone pain

Anemia

Heterochromia iridis (different colors of the iris or portions of the iris)

Hypertension

Unilateral nasal obstruction</p>