JHS Medical
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Medical
Poisonings
Drug Poisonings
Initial mgt, Drug poisonings
Clues to Dx (poisonings)
Blue Skin
Methemoglobinemia
Path, Methemoglobinemia
Reduction of MetHgb to Hgb
Alternative pathway, NOT physiologically active
Parents
Reduction of MetHgb to Hgb
Children
1. Utilizes NADPH generated by glucose-6-phosphate dehydrogenase (G6PD) in the hexose monophosphate shunt
2. However, there is normally no electron carrier present in RBCs to interact with NADPH methemoglobin reductase
3. Extrinsically Administered Electron Acceptors Are Needed: