Hoffman-La Roche (1896)
<p><strong>1930s</strong></p>
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<p><a href="https://nutritionrestored.com/blog-forum/topic/trying-to-decipher-the-bias-incompetence-fear-of-speaking-the-truth-and-conspiracy-around-the-mass-poisoning-done-with-vitamin-a/">Dr. Garrett Smith</a>:</p>
<p style="padding-left: 30px;">Here is the information I received from someone more knowledgeable in the history of this than I, as I find the links to back these statements, I will add them:
<em>"<span class="m_1986258385701740323m-6613260893433766664gmail-m_6210667015351277047gmail-m-4869262227875641414gmail-im">HR </span></em><span class="m_1986258385701740323m-6613260893433766664gmail-m_6210667015351277047gmail-m-4869262227875641414gmail-im">[Hoffman La-Roche]</span><em><span class="m_1986258385701740323m-6613260893433766664gmail-m_6210667015351277047gmail-m-4869262227875641414gmail-im"> was first given the patent for the synthetic manufactured VA, back in the mid 1930s, and they fund the early research.</span></em></p>
<p style="padding-left: 30px;">[<a href="https://pubs.acs.org/doi/abs/10.1021/ja01289a075">Harry Holmes and Ruth Corbet isolated and crystallized vitamin A in 1937</a>. I don't have the whole PDF to look for the sponsor. In terms of Roche's patents on Vitamin A related compounds: <a href="https://patents.google.com/?q=vitamin+a&assignee=Hoffmann+La+Roche">search results for Hoffman La-Roche patents for "Vitamin A"</a>, <a href="https://patents.google.com/?q=retinoic&assignee=Hoffmann+La+Roche">search results for Hoffman La-Roche patents for "retinoic"</a>, <a href="https://patents.google.com/?q=(retinoid)&assignee=Hoffmann+La+Roche">search results for Hoffman La-Roche patents for "retinoid"</a>. Have fun combing through those, there are a lot of them!]</p>
<p> </p>
<p><strong>1960s</strong></p>
<p> </p>
<p><a href="https://nutritionrestored.com/blog-forum/topic/trying-to-decipher-the-bias-incompetence-fear-of-speaking-the-truth-and-conspiracy-around-the-mass-poisoning-done-with-vitamin-a/">Dr. Garrett Smith</a>:</p>
<p style="padding-left: 30px;"><em><span class="m_1986258385701740323m-6613260893433766664gmail-m_6210667015351277047gmail-m-4869262227875641414gmail-im">They fund the Harvard research in the 1960s,</span></em></p>
<p style="padding-left: 30px;">[<a href="https://www.roche.com/about/history.htm">From the Roche website itself</a>, screenshot attached: <em>"Streamlining and improving pr</em><em>oduction - <strong>Vitamin output increases and new production locations strengthen Roche’s position as one of the main producers of vitamins</strong>. To avoid a strong dependency on vitamins, Roche intensifies pharmaceutical research. <strong>Between the early 1950s and mid-1960s pharmaceutical research is extremely diverse</strong>, with a portfolio of pharmaceuticals ranging from antidepressants and antimicrobials to <strong>agents for cancer chemotherapy.</strong></em>"]</p>
<p style="padding-left: 30px;"><em><span class="m_1986258385701740323m-6613260893433766664gmail-m_6210667015351277047gmail-m-4869262227875641414gmail-im">and later get a patent on 13 Cis-RA,</span></em></p>
<p style="padding-left: 30px;">[<a href="https://patents.google.com/patent/US4556518A/en">Hoffman La-Roche patent for 13-cis retinoic acid in 1982</a>]</p>
<p style="padding-left: 30px;"><em><span class="m_1986258385701740323m-6613260893433766664gmail-m_6210667015351277047gmail-m-4869262227875641414gmail-im">they then start selling RA as a chemo drug in the 1960s and 70s.</span></em></p>
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<p><strong>2000s</strong></p>
<p> </p>
<p>New York Times (2001):</p>
<p style="padding-left: 30px;"><em><strong>Hoffmann-La Roche of Switzerland was singled out as the ringleader and ordered to pay 462 million euros ($406 million), by far the biggest fine the European Union's competition authority has ever levied against a single company.</strong></em></p>