To Inoculate (transitive, immunology) To introduce an antigenic substance or vaccine into something (e.g. the body) or someone, such as to produce immunity to a specific disease. [from c. 1722] (transitive, by extension) To safeguard or protect something as if by inoculation. To add one substance to another. Synonym: spike To graft by inserting buds. [from c. 1420] (figuratively) To introduce into the mind (used especially of harmful ideas or principles). [from a. 1600] Synonyms: imbue, implant