(psychology) The experience of long-term exhaustion and diminished interest, especially in one's career.
(US, slang) A marijuana addict; one whose brains have been burned out.
(aerospace) The shutoff of a rocket motor following the complete exhaustion of its fuel supply, or having been irreversibly throttled after the application of a planned delta-v.
The failure of an electrical device, usually through overheating due to the application of excessive power. Burnout (vehicle) - Wikipedia
Using the throttle to spin the wheels of a vehicle being held stationary, causing the spinning tires to produce smoke and burn rubber.