To Annihilate

1. To reduce to nothing, to destroy, to eradicate.
2. (particle physics) To react with antimatter, producing gamma radiation.
3. (archaic) To treat as worthless, to vilify.
4. (transitive) To render null and void; to abrogate.

(to reduce to nothing): benothing, destroy, eradicate, extinguish

(to reduce to nothing): create, generate