A Disease

1. (pathology) An abnormal condition of a human, animal or plant that causes discomfort or dysfunction; distinct from injury insofar as the latter is usually instantaneously acquired.
2. (by extension) Any abnormal or harmful condition, as of society, people's attitudes, way of living etc.
3. Lack of ease; uneasiness; trouble; vexation; disquiet.

affliction

ailment

coath

complaint

ill health

illness

malady

medical condition

morbus

rot

sickness