A Degeneration (uncountable) The process or state of growing worse, or the state of having become worse. (uncountable) That condition of a tissue or an organ in which its vitality has become either diminished or perverted; a substitution of a lower for a higher form of structure. (uncountable) Gradual deterioration, from natural causes, of any class of animals or plants or any particular organ or organs; hereditary degradation of type. (countable) A thing that has degenerated. Synonyms (process or state of growing worse): decline, degradation, debasement, degeneracy, deterioration (gaming slang): nerf