In sense “to talk down”, the derived participial adjective condescending (and corresponding adverb condescendingly) are more common than the verb itself.
In older usage, "condescend" could be used non-pejoratively (in a sense similar to that of treating someone as inferior) to describe the action of those who socialized in a friendly way with their social inferiors. Now that the concept of social inferiors has largely fallen out of currency, so has this non-pejorative sense. Thus, in w:Pride_and_Prejudice, a character could say of another, "I need not say you will be delighted with her. She is all affability and condescension.”