Refractory
<ol style="margin: 0px; padding: 0px 0px 0px 2.25em; border: 0px; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-stretch: inherit; line-height: inherit; font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Lato, Helvetica, Arial, sans-serif; vertical-align: baseline; background-image: none; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial; color: rgb(34, 34, 34);"><li style="margin: 0px 0px 10px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><a href="https://en.m.wiktionary.org/wiki/obstinate" title="obstinate" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">Obstinate</a> and <a href="https://en.m.wiktionary.org/wiki/unruly" title="unruly" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">unruly</a>; strongly <a href="https://en.m.wiktionary.org/wiki/opposed" title="opposed" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">opposed</a>to something.<dl style="margin: 0px 0px 0px 1em; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><dd style="margin: 0px 0px 0px 1em; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; overflow: auto;"><span class="nyms synonym" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><span class="defdate" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">Synonyms:</span> <span class="Latn" lang="en" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><a href="https://en.m.wiktionary.org/wiki/contrary#English" title="contrary" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">contrary</a></span> <span class="ib-brac qualifier-brac" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">(</span><span class="ib-content qualifier-content" style="margin: 0px; padding: 0px; border: 0px; font-style: italic; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">inanimates</span><span class="ib-brac qualifier-brac" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">)</span>, <span class="Latn" lang="en" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><a href="https://en.m.wiktionary.org/wiki/fractious#English" title="fractious" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">fractious</a></span>; <a href="https://en.m.wiktionary.org/wiki/Thesaurus:obstinate" title="Thesaurus:obstinate" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">obstinate</a></span></dd></dl></li><li style="margin: 0px 0px 10px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">Not affected by great <a href="https://en.m.wiktionary.org/wiki/heat" title="heat" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">heat</a>.</li><li style="margin: 0px 0px 10px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><span class="ib-brac" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">(</span><span class="ib-content" style="margin: 0px; padding: 0px; border: 0px; font-style: italic; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><a href="https://en.m.wiktionary.org/wiki/medicine" title="medicine" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">medicine</a></span><span class="ib-brac" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">)</span> <a href="https://en.m.wiktionary.org/wiki/difficult" title="difficult" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">Difficult</a> to <a href="https://en.m.wiktionary.org/wiki/treat" title="treat" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">treat</a>.</li><li style="margin-top: 0px; margin-right: 0px; margin-bottom: inherit; margin-left: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><span class="ib-brac" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">(</span><span class="ib-content" style="margin: 0px; padding: 0px; border: 0px; font-style: italic; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;"><a href="https://en.m.wiktionary.org/wiki/biology" title="biology" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">biology</a></span><span class="ib-brac" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none;">)</span> <a href="https://en.m.wiktionary.org/wiki/incapable" title="incapable" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">Incapable</a> of registering a <a href="https://en.m.wiktionary.org/wiki/reaction" title="reaction" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">reaction</a> or <a href="https://en.m.wiktionary.org/wiki/stimulus" title="stimulus" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; background: none; color: rgb(107, 75, 161);">stimulus</a>.</li></ol>