A Curse

1. A supernatural detriment or hindrance; a bane. Curse - Wikipedia
2. A prayer or imprecation that harm may befall someone.
3. The cause of great harm, evil, or misfortune; that which brings evil or severe affliction; torment.
4. A vulgar epithet.
5. (slang, dated, derogatory, usually with "the") A woman's menses.