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Calendula Studies

Phytochemical Constituents and Pharmacological Activities of Calendula officinalis Linn (Asteraceae): A Review

Total flavonoid content in varieties of *Calendula officinalis* L. originating from different countries and cultivated in Estonia

Genotoxicity of an extract of *Calendula officinalis* L.

Increased synthesis of a new oleanane-type saponin in hairy roots of marigold (*Calendula officinalis*) after treatment with jasmonic acid

The effects of drying on the chemical components of essential oils of *Calendula officinalis L.*

HPLC analysis of carotenoids in four varieties of Calendula officinalis L. flowers

Analysis of carotenoids in Calendula petals

HPLC analysis of carotenoids in four varieties of Calendula officinalis L. flowers

A New d-Lactone Containing Triterpene from the Flowers of *Calendula officinalis*

The Response of *Calendula officinalis* L. Essential Oil Constituents to Biofertilizer

Anti-inflammatory

The Role of Triterpenoids in the Topical Anti-Inflammatory Activity of *Calendula officinalis* Flowers

By means of a bioassay-oriented fractionation of the CO2 extract of Calendula flowers, the triterpenoids are shown as the most important anti-inflammatory principles of the drug. Among them, the faradiol monoester appears to be the most relevant principle for the activity of the drug, due to its quantitative prevalence. The unesterified faradiol, not present in the extract, is the most active of the tested compounds and equals indomethacin in activity, whereas the monools ψ-taraxasterol, lupeol, taraxasterol, and β-amyrin are less active than the free diol. The anti-inflammatory activity of different CO2 extracts is proportional to their content of faradiol monoester, which can be taken as a suitable parameter for the quality control of Calendula preparations.

Antioxidant

Protective properties of butanolic extract of the Calendula officinalis L.(marigold) against lipid peroxidation of rat liver microsomes and action as free radical scavenger*

Protective effect of Calendula officinalis Linn. flowers against 3-nitropropionic acid induced experimental Huntington’s disease in rats

Antioxidant Potential of an Extract of *Calendula officinalis.* Flowers *in Vitro*. and *in Vivo*.

Bioaccessibility and antioxidant activity of Calendula officinalis supercritical extract as affected by in vitro codigestion with olive oil.

Cancer

Antimutagenic activity of some saponins isolated from *Calendula officinalis L., C. arvensis L.* and *Hedera helix* L.

Total antioxidant and oxidant status of plasma and renal tissue of cisplatin-induced nephrotoxic rats: protection by floral extracts of *Calendula officinalisLinn*

Cytotoxic effect of chamomile (*Matricaria recutita*) and marigold (*Calendulaofficinalis*) extracts on human melanoma SK-MEL-2 and epidermoid carcinoma KB cells

Candida

Comparing the effects of *Calendula officinalis* and clotrimazole on vaginal Candidiasis: A randomized controlled trial

Gastrointestinal Effects

Protective Effect of *Calendula officinalis* (L.) Flower Extract in Acetic Acid–Induced Ulcerative Colitis in Rats

Medicinal Flowers. III.1) Marigold. (1): Hypoglycemic, Gastric Emptying Inhibitory, and Gastroprotective Principles and New Oleanane-Type Triterpene Oligoglycosides, Calendasaponins A, B, C, and D, from Egyptian Calendula officinalis

Hepatoprotective

Antifungal Activity of *Achillea santolina* L. and *Calendula officinalis* L. Essential Oils and Their Constituents Against Fungal Infection of Liver as Complication of Cyclophosphamide Therapy

Hepato and reno protective action of Calendula officinalis L. flower extract

Hepato and reno protective action of Calendula officinalis L. flower extract

Immune System Effects

A new extract of the plant *calendula officinalis produces* a dual *in vitro effect*: cytotoxic anti-tumor activity and lymphocyte activation

Structural analysis of a rhamnoarabinogalactan and arabinogalactans with immuno-stimulating activity from *Calendula officinalis*

Renoprotective

Hepato and reno protective action of Calendula officinalis L. flower extract

Skin Diseases

C. officinalis flowers can be used as a natural source of antimelanogenisis and antimigration regent to treatment or prevent skin diseases.

Phase III Randomized Trial of *Calendula Officinalis* Compared With Trolamine for the Prevention of Acute Dermatitis During Irradiation for Breast Cancer

Spasms

Studies on spasmogenic and spasmolytic activities of *Calendula officinalis* flowers

Wound Healing

Induction of vascularisation by an aqueous extract of the flowers of *Calendula officinalis* L. the European marigold

Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers.

C. officinalis potentiated wound healing by stimulating the expression of CTGF and α-SMA.

Calendula officinalis extract is an effective treatment for venous leg ulcers.

Wound Healing and Anti-Inflammatory Effect in Animal Models of *Calendula officinalis* L. Growing in Brazil

These results contribute to a better understanding of the wound healing properties of the traditional medicinal plant Calendula officinalis

A systematic review of Calendula officinalis extract for wound healing.

Other Effects

*Calendula officinalis* ameliorates l-arginine-induced acute necrotizing pancreatitis in rats

Calendula officinalis stimulate proliferation of mouse embryonic fibroblasts.

Genotoxicity of an extract of *Calendula officinalis* L.

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