Neem, Studies

• Harnessing the Phytotherapeutic Treasure Troves of the Ancient Medicinal Plant Azadirachta indica (Neem) and Associated Endophytic Microorganisms.
• Comprehensive analyses of genomes, transcriptomes and metabolites of neem tree.
• Prospective Role of Indian Medicinal Plants in Inhibiting Vascular Endothelial Growth Factor (VEGF) mediated Pathological Angiogenesis

Alzheimer’s

Computational evaluation of Azadirachta indica-derived bioactive compounds as potential inhibitors of NLRP3 in the treatment of Alzheimer's disease.

Antibacterial

• In vitro efficacy of Azadirachta indica leaf extract against methicillin resistant Staphylococci isolated from skin infection.
• Azadirachta indica fruit mesocarp and epicarp extracts induce antimicrobial and antiproliferative effects.
• Antibacterial and antiproliferative activities of Azadirachta indica leaf extract.

Antifungal

Antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens

Antiparasitic

New antitrypanosomal tetranotriterpenoids from Azadirachta indica.

Antiviral

• Neem compounds have potential activity against influenza viruses.
• In silico evaluation of inhibitory potential of triterpenoids from Azadirachta indica against therapeutic target of dengue virus, NS2B-NS3 protease.

Anxiety / Depression

Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica.

Cancer

• Azadirachta indica modulates carcinogen biotransformation and reduced glutathione at peri-initiation phase of benzo(a)pyrene induced murine forestomach tumorigenesis
• A study on antioxidant and apoptotic effect of Azadirachta Indica (neem) in cases of cervical cancer
• P-gp modulating effect of Azadirachta indica extract in multidrug-resistant cancer cell lines
• Evaluation of Apoptosis and Autophagy Inducing Potential of *Berberis aristata, Azadirachta indica*, and Their Synergistic Combinations in Parental and Resistant Human Osteosarcoma Cells.
• Exploring the therapeutic potential of neem for the treatment of prostate cancer.
• Methanolic neem stem bark extract induces cell cycle arrest, apoptosis and inhibits the migration of cervical cancer cells.

Cardiovascular

• Azadirachta indica provides cardio protection by ameliorating oxidative stress

Cholera

• Antibacterial, antisecretory and antihemorrhagic activity of Azadirachta indica used to treat cholera and diarrhea in India. Journal of ethnopharmacology.

COVID-19

Bark of neem tree may protect against coronavirus variants, study finds (https://www.sciencedaily.com/releases/2022/02/220228114351.htm) Extract from the bark of the Neem tree may help treat and reduce the spread of coronavirus, according to a new study. The research shows that components of Neem bark may target a wide range of viral proteins, suggesting its potential as an antiviral agent against emerging variants of coronaviruses (including SARS-CoV-2).

Diabetes

• Therapeutic role of Azadirachta indica leaves ethanolic extract against diabetic nephropathy in rats neonatally induced by streptozotocin.
• Combating effects of Azadirachta indica leaves extract on biochemical and neuropsychological decline observed in diabetes.

Dyslipidemia

Exploring the prophylactic potential of Azadirachta indica leaf extract against dyslipidemia.

Fluoride Removal

• Thermally activated carbon prepared from neem and acacia arabica leaves were found to have fluoride removal properties.

Gingivitis

• Effect of various mouthwashes on the levels of interleukin-2 and interferon-gamma in chronic gingivitis.

Insulin Resistance

Aqueous Azadirachta indica extract attenuates insulin resistance to improve glycemic control and endothelial function.

Neuroprotective

• Neuroprotective effect of Azadirachta indica standardized extract in partial sciatic nerve injury in rats: Evidence from anti-inflammatory, antioxidant and anti-apoptotic studies
• Anti‑oxidative and anti‑apoptotic neuroprotective effects of Azadirachta indica in Parkinson‑induced functional damage
• Neem Derivatives Inhibits Tau Aggregation.
• Effects of Azadirachta indica on neuropathic pain induced by chronic constriction injury to sciatic nerve of Wistar rat.

Oral Health

Panacea in dentistry – An update

Other Effects

• The present study points out the protective effects of A. indica extract on pyramidal neurons in experimental cerebral malaria induced by P. berghei-infection in mice.