Antithrombin

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Antithrombin (ATIII) is a protein in the blood that regulates blood clotting. It's a nonvitamin K-dependent protease that inactivates several enzymes in the coagulation cascade. These enzymes include:

Thrombin, Factor Xa, Factor IXa, Factor XIa, Factor XIIa, Factor VIIa.

Antithrombin is the primary inhibitor of thrombin, which is required for blood clots to develop. It also inhibits two clotting factors, factor Xa and factor IXa, which are required to generate thrombin.

Antithrombin deficiency is a blood clotting problem that can put you at risk for a dangerous blood clot. This deficiency can lead to:

• Deep vein thrombosis (DVT) in your leg
• Pulmonary embolism in your lung

Some drugs that target antithrombin include: Edoxaban, Desirudin, Fondaparinux