Sourop/Graviola Cautions

<a href="HTTPS://WWW.NUTRAINGREDIENTS-USA.COM/ARTICLE/2012/05/10/TOXICOLOGY-EXPERT-RAISES-ALARM-OVER-POTENTIAL-NEUROTOXINS-IN-GRAVIOLA-SOURSOP">Toxicology expert raises alarm over potential neurotoxins in graviola/soursop</a>

<a href="http://www.ncbi.nlm.nih.gov/pubmed/9848004">Tropical myeloneuropathies revisited.</a>

Alkaloids present in graviola caused movement disorders and myeloneuropathy with symptoms mimicking Parkinson’s disease in vitro. Clinical significance is not known.

<a href="http://www.ncbi.nlm.nih.gov/pubmed/11835443" target="_blank">Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe.</a>

<a href="http://www.ncbi.nlm.nih.gov/pubmed/17017523" target="_blank">Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?</a>

<a href="http://www.ncbi.nlm.nih.gov/pubmed/23712095" target="_blank">Antitumor activity and toxicity relationship of annonaceous acetogenins</a>

<a href="http://www.ncbi.nlm.nih.gov/pubmed/27569447" target="_blank">Chronic consumption of</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/27569447">Annona muricata</a> juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice.

<h2>Drug Interactions</h2>

Antidiabetics: Graviola showed hypoglycemic effects in a murine model , and can have additive effects with antidiabetic drugs. Clinical relevance is not known.
Antihypertensives: Graviola showed hypotensive effects in a murine model , and can have additive effects with antihypertensive medications. Clinical relevance has yet to be determined.

<a href="http://www.ncbi.nlm.nih.gov/pubmed/24626725" target="_blank">Influence of</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/24626725">Annona muricata</a> (soursop) on biodistribution of radiopharmaceuticals in rats

<a href="http://www.ncbi.nlm.nih.gov/pubmed/24353141" target="_blank">Toxicological evaluation of the lyophilized fruit juice extract of</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/24353141">Annona muricata</a> Linn. (Annonaceae) in rodents.

<h2>Lab Interactions</h2>

Nuclear imaging (radiopharmaceutical biodistribution): Graviola significantly decreased uptake of radioactivity per gram of tissue in bladder, kidney, and blood in animal models .
Blood glucose test: Graviola reduced blood glucose levels in a murine model .
Blood pressure readings: Graviola reduced blood pressure readings in a murine model