Vitamin B Complex

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Vitamin B Complex

Low B-vitamins with adrenal issues and SIBO

B Vitamins - What You Need To Know

Can B Vitamin Deficiencies LITERALLY Make You Go Crazy?

The gut flora produces numerous B vitamins (and weight loss compounds). If B vitamins are low it means the microbiome is unhealthy.

B-Complex: One of the few vitamin categories that has been confirmed in human studies to not only reduce the progression of plaque buildup in the arteries but actually reverse it is B-complex. A 2009 study published in the journal Stroke found that high dose B-complex vitamin supplementation significantly reduces the progression of early-stage subclinical atherosclerosis in healthy individuals.More remarkably, a 2005 study published in the journal Atherosclerosis found a B-vitamin formula decreased the carotid artery thickness in patients at risk for cerebral ischemia. Another possible explanation for these positive effects is the role B-vitamins have in reducing the production of Homocysteine, an artery and otherwise blood vessel scarring amino acid.

If a vitamin B supplement is synthetic, it will most likely be listed as folic acid. To avoid this, choose active B vitamins, which are sold under the following common names :

Thiamine (B1): Thiamine pyrophosphate; Thiamine triphosphate

Riboflavin (B2): Riboflavin-5-phosphate; Flavin mononucleotide (FMN)

Niacin (B3): Nicotinamide (adenine dinucleotide)

Pantothenic acid (B5): Pantethine

Pyridoxine (B6): Pyridoxal-5-phosphate

Folic acid: Folinic acid; 5-methyl tetrahydrofolate

Cobalamin (B12): Methylcobalamin; Adenosylcobalamin

Choline: Phosphatydlcholine

Don’t take B vitamins before bed, they stimulate the nervous system.

Source for: Premier Max B-ND Live Source B Vitamins

Best Sources

Vegetables (especially leafy green)
Legumes
Whole grains
Seeds, nuts
Meat, fish, poultry
Milk products

Effects on Immune System

There is a strong link between B vitamins and host immune response to infections. Vitamins B₁, B₂, and B₅ control the host immune response through the regulation of energy generation in various immune cells ^[R]. Vitamin B₁ deficiency impairs the maintenance of B cells, whereas vitamin B₃ regulates the differentiation of T cells, decreases the production of several proinflammatory cytokines, and downregulates transforming growth factor-β gene expression and NF-kB activity ^[R]. Vitamin B₅ deficiency causes inflammation through the higher production of proinflammatory mediators ^[RFurthermore, vitamin B₅ activates the phagocytic activity of macrophages, enhances the production of IL-6 and TNF-α, and modulates Th1 and Th17 responses ^[R]. Vitamin B₆ deficiency leads to lymphocytopenia and excessive Th2 responses and lowers lymphoid tissue weight and antibody responses ^[R]. Vitamin B₆ mobilizes to the sites of inflammation where it may serve as a cofactor in pathways producing mediators with anti-inflammatory effects ^[R]. The plasma level of vitamin B6 is inversely associated with several inflammatory biomarkers in population-based investigations ^[R]. Vitamin B₉ deficiency causes an impaired immune response and the reduced blastogenic response of T lymphocytes ^[R]. Vitamin B₁₂ maintains the function and proliferation of NK cell and CD8⁺ T cells. Deficiency in vitamin B₁₂ leads to a reduction in the number of NK cells and IL-6 levels as well as an enhancement of CD4⁺/CD8⁺ ratio and TNF-α value ^[R].

There are several experimental and clinical studies indicating the antiviral effects of B vitamins. Patients with HIV had a high prevalence of vitamin B₁ deficiency. Vitamin B₁ affects HIV infection via non-genomic mechanisms, which may lead to beneficial effects in patients with HIV ^[R]. Vitamin B₂ alone or in combination with ulratraviolet light has a potent antiviral effect on a wide range of viruses, such as MERS-CoV ^[R]. Deficiencies in vitamins B₆, B₉, and B₁₂ render people more susceptible to viral respiratory infections, such as influenza ^[R]. It has been suggested that a vitamin A–vitamin B₆ conjugate analog can exert an antiviral effect by regulating transcription and/or replication of various RNA viruses, including coronavirus ^[R].

Effects of Deficiency on Mood

Depression, vague fears
Emotional instability
Decreased ability to cope with problems
Confusion, forgetfulness
Irritability, quarrelsome

Conditions Affecting B-vitamin Levels:

Metformin (used to normalize elevated blood sugar – Type II diabetes; polycystic ovary disease):
- Increases risk of B-12 deficiency
- Some studies show association with lower folate levels

Genetics role:

1% of US population have MTHFR - Methylenetetrahydrofolate reductase polymorphism
Associated with lower folate levels

People with MTHFR polymorphism are in pretty good shape if getting folate from food but if you aren’t eating a vitamin B rich diet and are getting folate in the form of folic acid supplements or fortified foods, you many not be able to take that form of folic acid and get it into its metabolically active form.