Java Tea Studies

Antibacterial

Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation.

Polymethoxylated flavones from Orthosiphon stamineus leaves as antiadhesive compounds against uropathogenic E. coli.

Arthritis

Orthosiphon stamineus tea modulates arthritis pathogenesis.

Blood Sugar

• Orthosiphol A from the aerial parts of Orthosiphon aristatus is putatively responsible for hypoglycemic effect via alpha-glucosidase inhibition.
• Evaluation of α-glucosidase inhibitory effect of 50% ethanolic standardized extract of Orthosiphon stamineus.
• Hexane extract of Orthosiphon stamineus induces insulin expression and prevents glucotoxicity in INS-1 cells.
• Glucose uptake stimulatory and PTP1B inhibitory activities of pimarane diterpenes from Orthosiphon stamineus.

Cancer

Toxicological studies of Orthosiphon stamineus standardized ethanol extract in combination with gemcitabine.

Dementia

Orthosiphon stamineus standardized extract reverses streptozotocin-induced Alzheimer's disease-like condition.

Diabetes

Potent alpha-glucosidase and alpha-amylase inhibitory activities of standardized 50% ethanolic extracts and sinensetin from Orthosiphon stamineus Benth as anti-diabetic mechanism.

Gastroprotective

A comparative study of the antioxidant and intestinal protective effects of extracts from different parts of Java tea.

Urinary Tract

• O. grandiflorum has a significant inhibitory effect on crystal deposition in the calcium oxalate-stone-forming model.
• Aqueous extract from Orthosiphon stamineus leaves prevents bladder and kidney infection in mice

Memory

An ethanolic extract of O. stamineus leaves improves memory by reversing age-related deficits in short-term social memory.

Nephroprotective

These findings demonstrate that Orthosiphon stamineus extracts have antihyperuricemic and nephroprotective effects.

Obesity

Antiobesity and lipid lowering effects of Orthosiphon stamineus in high-fat diet-induced obesity.

Renoprotective

Urinary metabolic profiling of cisplatin nephrotoxicity and nephroprotective effects of Orthosiphon stamineus leaves.

Other Effects

On the effects of a plant extract of Orthosiphon stamineus on sebum-related skin imperfections.

50% Ethanol extract of Orthosiphon stamineus modulates genotoxicity and clastogenicity induced by mitomycin C.

Flavonoids-rich Orthosiphon stamineus extract as new candidate for angiotensin I-converting enzyme inhibition.