CHRNA7

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CHRNA7 is a protein-coding gene that stands for cholinergic receptor nicotinic alpha 7 subunit. It is genetically linked to multiple disorders with cognitive deficits, including:

Schizophrenia, Bipolar disorder, ADHD, Epilepsy, Alzheimer's disease, Rett syndrome.

The CHRNA7 gene encodes the alpha7 nicotinic acetylcholine receptor. This receptor is widely expressed throughout the CNS in neurons and glial cells, and facilitates fast synaptic signal transmission. It is stimulated by choline and acetylcholine to trigger calcium, sodium, and potassium cation flux.

The CHRNA7 gene is considered a potential target for therapeutic intervention.