Spearmint, Studies

• Pharmacological Evaluation of Mentha spicata L. and Plantago major L., Medicinal Plants Used to Treat Anxiety and Insomnia in Colombian Caribbean Coast.
• Phytochemical Characterization of Mentha spicata L. Under Differential Dried-Conditions and Associated Nephrotoxicity Screening of Main Compound With Organ-on-a-Chip.
• The attention-enhancing effects of spearmint extract supplementation in healthy men and women: a randomized, double-blind, placebo-controlled, parallel trial.

Antioxidant

• Antioxidant activity measured in different solvent fractions obtained from Mentha spicata Linn.: an analysis by ABTS*+ decolorization assay.
• Analysis of Indian mint (Mentha spicata) for essential, trace and toxic elements and its antioxidant behaviour

Arthritis

• Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata.
• High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms.

Cancer

Antiemetic in the treatment of cancer - Mechanistically, it is quite possible that the free radical scavenging and the antioxidant effects of mint may have contributed to the reduction in CTA. Studies have also shown that rotundifolone, an active constituent of mint oil, mimics the effects produced by calcium channel blockers, and thus can neutralize the injurious effects of biogenic amines such as histamines and 5-HT and also modulate vagal activity and reduce intestinal motility and contractility. Mint oil is also known to exert neurobehavioral effects, increase alertness, sharpen mental process, and rejuvenate a sluggish and tired mind. All these properties may have contributed to the observed effect.

Evidence of biological activity of Mentha species extracts on apoptotic and autophagic targets on murine RAW264.7 and human U937 monocytic cells.

Diabetes

Study of Hypoglycemic, Hypocholesterolemic and Antioxidant Activities of Iranian Mentha Spicata Leaves Aqueous Extract in Diabetic Rats.

DNA Protection

Protective effects of solvent fractions of Mentha spicata (L.) leaves evaluated on 4-nitroquinoline-1-oxide induced chromosome damage and apoptosis in mouse bone marrow cells.

Gastrointestinal Effects

Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice.

Hirsutism

Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism

Memory

Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment.

Neuroprotective

• Chronic dietary ingestion of suitable phytochemicals may assist with limiting or negating neurodegenerative decline. Current therapeutics used to treat Alzheimer disease elicit broad adverse drug reactions, and alternative sources of cholinesterase inhibitors (ChEIs) are required. Herein, we screened methanolic extracts from seven commonly cultivated plants for their nutraceutical potential; ability to inhibit acetylcholinesterase (AChE) and butyryl-cholinesterase (BuChE), and provision of antioxidant activity through their 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) free radical scavenging capabilities...Mentha spicata (Spearmint) displayed concentration-dependent inhibition of AChE and BuChE...chronic consumption may prove beneficial to combat the pathological deficits that accrue in Alzheimer disease Study
• Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia.
• Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury.

Obesity / Overweight

Spearmint possesses strong antioxidant and pancreatic lipase inhibitory activities with potential applications in the treatment and prevention of obesity and overweight.

PCOS

Spearmint Tea Shown to Have Positive Effect On Polycystic Ovarian Syndrome

• The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to be Pregnant: A Randomized Clinical Trial
• A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS.