SARS-COV-2
This is an RNA virus, meaning it can mutate very quickly. RNA viruses are more dangerous to humans.
Cellular entry of SARS-CoV-2 is mediated by the binding of the viral spike (S) protein to its cellular receptor, angiotensin-converting enzyme 2 (ACE2)4,5. Other host entry factors have been identified, including neuropilin-1 and TMPRSS2, a transmembrane serine protease involved in S protein maturation. The SARS-CoV-2 S protein consists of the S1 subunit, which contains the receptor binding domain (RBD), and the S2 subunit, which mediates membrane fusion for viral entry8. A major goal of vaccine and therapeutic development is to generate antibodies that prevent the entry of SARS-CoV-2 into cells by blocking either ACE2–RBD binding interactions or S-mediated membrane fusion.
The spike protein has about 1,273 amino acids.
Chrysin 7-O-β-D-glucuronide, a dual inhibitor of SARS-CoV-2 3CLpro and PLpro.
Video Spike Genes Have Patented DNA Sequences. This is Dangerous.
SARS-CoV-2 coronavirus in water and wastewater: A critical review about presence and concern
Sewer slime can hang on to SARS-CoV-2 RNA from wastewater (https://www.sciencedaily.com/releases/2022/02/220209093450.htm)
27 Epitopes In The Spike Protein Match Up To Human Reproductive Proteins…
Stunning new research published in *Viruses*, part of the SARS-CoV-2 Host Cell Interactions edition of MDPI (Open Access Journals) reveals that vaccine spike proteins enter cell nuclei and wreak havoc on cells’ DNA repair mechanism, suppressing DNA repair by as much as 90%.
The research paper is entitled, “SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro” and is authored by Hui Jiang and Ya-Fang Mei, at the Department of Molecular Biosciences, The Wenner–Gren Institute, Stockholm University, SE-10691 Stockholm, Sweden, and the Department of Clinical Microbiology, Virology, Umeå University, SE-90185 Umeå, Sweden, respectively.
In the conclusion of the paper, authors write, “We found that the spike protein markedly inhibited both BRCA1 and 53BP1 foci formation (Figure 3D–G). Together, these data show that the SARS–CoV–2 full–length spike protein inhibits DNA damage repair by hindering DNA repair protein recruitment.”
The DNA repair mechanism, known as NHEJ (Non-Homologous End Joining) is a kind of intracellular “emergency response” system that repairs double-stranded DNA breaks. Without the NHEJ mechanism, all advanced multi-cellular life would cease to exist. No human being, animal or plant can survive with the integrity of its genetic code being protected and constantly repaired through multiple mechanisms. A pdf is available here
Video How SARS-CoV-2 inhibits T-cells and B-cells, Dr. Paul Cottrell
Video: Evolutionary Dynamics of SARS-CoV-2
Video SARS-Cov-2 effects on sertoli, leydig and germ cells (r)) by Dr. Paul Cottrell
Tomatidine and patchouli alcohol as inhibitors of SARS-CoV-2 enzymes.
COVID-19: Achilles’ Heel of SARS-CoV-2 Viral RNA Identified
COVID-19 Virus Produces microRNA That Can Have Impacts on Infected Cells
April 30, 2021 THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY ROLE IN ILLNESS
Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease
Collapsing COVID: MIT Says Ultrasound Can Damage Coronaviruses
The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice Remember ALL the vaccines either have the spike, or get your cells to make the spike via mRNA...Then, remember the spikes alone can cross the Blood-Brain-Barrier
SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques
March 2021, Video: Isolation and Sequencing of Sars-CoV-2 with Dr. Paul Cottrell
Molecular Docking Study on Several Benzoic Acid Derivatives against SARS-CoV-2.
Researchers succeed in photo of the coronavirus
Pioneering Computational Model of Entire SARS-CoV-2 Virus Responsible for COVID-19
Comparative Review of SARS-CoV-2, SARS-CoV, MERS-CoV, and Influenza A Respiratory Viruses
Folding of SARS-CoV2 Genome Reveals COVID-19 Drug Targets – And Preparation for “SARS-CoV3”
Coronaviruses closely related to the pandemic virus discovered in Japan and Cambodia - The viruses, both found in bats stored in laboratory freezers, are the first SARS-CoV-2 relatives to be found outside China.
Mysterious New “Hidden” Gene Discovered in COVID-19 Virus
Visualizing The Relative Size Of Particles (Like COVID-19)
Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase
Artesunate induces substantial topological alterations in the SARS-CoV-2 Nsp1 protein structure.
An in-silico evaluation of dietary components for structural inhibition of SARS-Cov-2 main protease. The main protease (M) of SARS-CoV-2 is responsible for the cleavage of viral replicase polyproteins 1a and 1ab into their mature form and is highly specific and exclusive in its activity. Many studies have targeted this enzyme by small molecule inhibitors to develop therapeutics against the highly infectious disease Covid-19. Our diet contains many natural antioxidants which along with providing support for proper growth and functioning of the body, pose additional health benefits. Present in-silico analysis depicted that natural antioxidants like sesamin, ellagic acid, capsaisin, and epicatechin along with galangin, exhibited significant binding at the catalytic site of the Menzyme. They interacted with excellent efficiency with the chief active site residue Cys145 and thus seem to possess the remarkable potential to act as drug candidates for the treatment of Covid-19. Such dietary compounds can be easily administered orally with least toxicity related concern and thus yell for urgent exhaustive research to develop into efficient therapies.