Fucoidans, Studies
The Potential Use of Fucoidans from Brown Seaweed as a Dietary Supplement https://www.longdom.org/open-access/the-potential-use-of-fucoidans-from-brown-seaweed-as-a-dietary-supplement-2155-9600.1000171.pdf
Allergies
The role of algal fucoidans in potential anti-allergic therapeutics.
Anti-bacterial
- Antibacterial efficacy of a fucoidan fraction extracted from Sargassum polycystum.
- Fucoidan from Sargassum hemiphyllum inhibits infection and inflammation of Helicobacter pylori.
Anti-inflammatory
- Fucoidan reduces inflammatory response in a rat model of hepatic ischemia-reperfusion injury.
- Low molecular weight fucoidan fraction ameliorates inflammation and deterioration of skin barrier in fine-dust stimulated keratinocytes.
- Anti-inflammatory effect of fucoidan isolated from fermented Sargassum fusiforme in in vitro and in vivo models.
Antioxidant
Fucoidan could be implemented as a beneficial antioxidant agent.
Antiviral
- Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2.
- Novel antiviral fucoidan from sporophyll of Undaria pinnatifida (Mekabu)
- Defensive effects of a fucoidan from brown algae Undaria pinnatifida against herpes simplex virus infection.
- Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease.
- Inhibition of dengue virus infection in vitro by fucoidan and polysaccharide extract from marine alga Sargassum.
Asthma
Bones
Cancer
- A review of fucoidan which induces cell death within tumor cells and increases the survival rate of tumor-bearing animal models by suppression of metastasis and angiogenesis.
- Fucoidan increased MDA levels in MCF-7 cells, indicating its anticancer properties through the induction of apoptosis.
- Fucoidan enhances the anti-tumor effect of anti-PD-1 immunotherapy by regulating gut microbiota.
- Seaweeds in the oncology arena: Anti-cancer potential of fucoidan.
- Antitumor activity of fucoidan: a systematic review and meta-analysis.
- The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations.
- Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposide
- Enhanced anticancer effect of ROS-boosted photothermal therapy by using fucoidan-coated polypyrrole nanoparticles.
- The carotenoid fucoxanthin can sensitize multidrug resistant cancer cells to doxorubicin.
- Structure and chemopreventive activity of fucoidans from the brown alga Alaria angusta.
- Fucoidan from Sargassum hemiphyllum inhibits the stemness of cancer stem cells and epithelial-mesenchymal transitions in bladder cancer cells.
- Fucoidan may be a promising therapeutic agent for human **breast cancers**.
- Fucoidan from Lessonia trabeculata induces apoptosis through caspase dependent and caspase-independent activation in 4T1 **breast adenocarcinoma**.
- Inhibition of fucoidan on breast cancer cells and potential enhancement of their sensitivity to chemotherapy by regulating autophagy.
- Fucoidan seems to be promising anti-cancer agent for **endometrial stromal sarcoma and carcinosarcoma**.
- Fucoidans inhibited colony formation and growth of **melanoma and colon cancer cells**.
- Fucoidan may be a potential adjuvant therapy for cancer patients treated with cisplatin as it preserves renal functionality.
- Modulation of human endothelial cell proliferation and migration by fucoidan and heparin
- Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK, JAK/STAT, AP-1 and IRF-1, and depends on up-regulation of scavenger receptor B1 expression in TNF-alpha- and IFN-gamma-stimulated C6 glioma cells.
- **Antitumor** activity and immune response of Mekabu fucoidan extracted from Sporophyll of Undaria pinnatifida.
- Fucoidan extracted from Cladosiphon okamuranus tokida induces apoptosis of human **T-cell leukemia **virus type 1-infected T-cell lines and primary adult T-cell leukemia cells
- Inhibitory effect of fucoidan on the adhesion of **adenocarcinoma** cells to fibronectin.
- Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities
- Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk Sea Fucus evanescens brown alga.
- Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and **tumor progression**.
- Inhibitory effect of fucoidan on Huh7 **hepatoma **cells through downregulation of CXCL12
- Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer.
- Dietary fucoidan of Acaudina molpadioides alters gut microbiota and mitigates intestinal mucosal injury induced by cyclophosphamide.
- An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients.
- Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human **colon cancer **cells
- Fucoidan induces apoptosis of HT-29 cells. colorectal adenocarcinoma
- In vitro anticancer activity of fucoidan extracted from Sargassum cinereum against Caco-2 cells. Colon cancer
- Fucoidan may be a potential therapeutic reagent against the growth of human **colon cancer** cells.
- Fucoidan extract caused about 50% cell death in colon cancer cell line HCT-15. Colon Cancer
- Fucoidan immobilized at the surface of a fibrous mesh presents toxic effects over**melanoma** cells, but not over non-cancer skin cells.
- The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing **melanoma** growth inhibition
- Fucoidan ameliorates **hepatocellular carcinoma**.
- Fucoidan inhibits the progression of **hepatocellular carcinoma**.
- Antimetastatic effect of fucoidan-sargassum against **liver cancer **cell Invadopodia formation.
- Fucoidan could dose-dependently inhibit cell viability and proliferation of DU-145 cells. (Prostate cancer)
- Administration of fucoidan to DU-145 prostate-bearing nude mice significantly reduced tumor volume and tumor weight. Prostate cancer
- Fucoidan inhibits tumor lymphangiogenesis and lymphatic metastasis.
- Fucoidan could be used as a promising antitumor agent targeting macrophages for tumor immunotherapies.
- Fucoidan was able to interfere with angiogenesis of **multiple myeloma cells** both in vitro and in vivo.
- Low molecular weight fucoidan is a potential agent for preventing **cancer cachexia**-associated muscle atrophy during chemotherapy.
- Fucoidan could induce apoptosis and the inhibition of telomerase activity in **bladder cancer** cells.
- Fucoidan may suppress cellular proliferation and DNA synthesis in MKN45 cells by suppressing the ASK1-p38 signaling pathway through a reduction in phosphorylated ASK1 levels.
- Fucoidan induces ROS-dependent epigenetic modulation in **cervical cancer** HeLa cell.
- Fucoidan/UVC combined treatment exerts preferential antiproliferation in **oral cancer cells** but not normal cells.
- Fucoidan suppressed the proliferation and induced apoptosis through the intrinsic and extrinsic pathways in the **acute promyelocytic leukemia (APL)** cell lines NB4 and HL60
- Some fucoidan extracts hindered long-term colony formation by HCT116 cancer cells.
- Fucoidan MF4 from Fucus vesiculosus inhibits Lewis lung cancer.
Cardiovascular Effects
- Overall results showed a high anticoagulant activity of fucoidan from the sea cucumber Holothuria polii.
- Anticoagulant properties of a fucoïdan fraction
- Pilot clinical study to evaluate the anticoagulant activity of fucoidan.
- Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin.
- Modulation of platelet aggregation-related eicosanoid production by dietary F-fucoidan from brown alga Laminaria japonica in human subjects
- Fucoidan supplementation appears to have anti-dyslipidemic and anti-atherosclerotic effects.
- Anti-hyperlipidemic effect of fucoidan fractions prepared from Iceland brown Algae Ascophyllum nodosum.
Cerebrovascular
- These findings indicate that pretreated fucoidan can relieve the acceleration and exacerbation of ischemic brain injury in an obese state.
- Fucoidan could play a protective role in cerebral ischemia-reperfusion injury.
- Fucoidan can be used as a useful preventive agent in cerebral ischemia.
COVID-19
- Ex vivo treatment with fucoidan of mononuclear cells from SARS-CoV-2 infected patients.
- Fucoidan may be a potential treatment to diminish long-term sequelae from COVID-19.
- These results indicate that natural fucoidan with higher molecular weight are more effective to inhibit these pathogenic bacteria and SARS-CoV-2.
- Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin.
- Deciphering the role of fucoidan from brown macroalgae in inhibiting SARS-CoV-2.
- Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxis.
Diabetes
- Fucoidan fulfilled the pharmacokinetic properties thus promising to develop fucoidan as drug for type 2 DM.
- Fucoidan from Laminaria japonica ameliorates type 2 diabetes mellitus.
- Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats.
- Low molecular weight fucoidan may have therapeutic potential against diabetic nephropathy.
- Fucoidan mitigated diabetic nephropathy.
- Oligo-Fucoidan Improves Diabetes-Induced Renal Fibrosis via Activation of Sirt-1, GLP-1R, and Nrf2/HO-1: An In Vitro and In Vivo Study.
- Fucoidan may stimulate insulin secretion and provide pancreatic protection via the cAMP signaling pathway, in vivo and in vitro.
- Low molecular weight fucoidan can inhibit the fibrosis of diabetic kidneys by regulating the kidney lipid metabolism.
- Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
- Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
- Fucoidan improves early stage diabetic nephropathy.
Endometriosis
Eyes
Gastroprotective
- Wheat peptides and fucoidan intervention could be utilized as a nutritional alternative to mitigate the progression of chronic gastritis.
- Fucoidan Extracts Ameliorate Acute Colitis
- Effect of fucoidan on aspirin-induced stomach ulceration in rats.
- Immunomodulatory activity of fucoidan against aspirin-induced gastric mucosal damage in rats
- Oral fucoidan preparations significantly reduce the inflammatory pathology associated with DSS-induced colitis.
- Curative effects of fucoidan on acetic acid induced ulcerative colitis,
- Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis.
- Fucoidan mitigates gastric ulcer injury through managing inflammation, oxidative stress, and NLRP3-mediated pyroptosis.
- Fucoidan alleviated dextran sulfate sodium-induced ulcerative colitis.
- A fucoidan plant drink reduces Helicobacter pylori load in the stomach.
Hepatoprotective
- Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease.
- Protective effects of fucoidan against ethanol-induced liver injury.
- Fucoidan from Apostichopus japonicus ameliorates alcoholic liver disease by regulating gut-liver axis homeostasis.
Hypolipidermic
- Hypolipidemic effects of fucoidan fractions from Saccharina sculpera.
- Dietary fucoidan from a brown marine algae attenuates lipid accumulation.
Immunomodulatory
- These results indicated that fucoidan modulated cellular and humoral immunity.
- The fucoidan has reduced LPS induced cytotoxicity in IC-21 macrophage at a dose depended on manner.
Liver Effects
- Fucoidan: Biological Activity in Liver Diseases
- Fucoidan ameliorates hepatic ischemia-reperfusion injury in mice.
- Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells. (Bladderwrack)
- "Suppression by fucoidan of liver fibrogenesis via the TGF-β/Smad pathway in protecting against oxidative stress."
Macular Degeneration
Metabolic Syndrome
Anti-metabolic syndrome effects of fucoidan from Fucus vesiculosus.
Mycoplasma pneumonia
Neuroprotective
- "Fucoidan protects against dopaminergic neuron death in vivo and in vitro."
- Fucoidan may have neuroprotective effects on Parkinson disease.
- Fucoidan protects against dopaminergic neuron death in vivo and in vitro.
- Fucoidan serves a neuroprotective effect in an Alzheimer's disease model.
- These findings also suggest that fucoidan could potentially be used as a therapeutic agent for Parkinson's disease.
- Fucoidan might protect the central nervous system against diesel exhaust particles exposure.
- Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice.
Obesity/Overweight
- Effect of fucoidan administration on insulin secretion and insulin resistance in overweight or obese adults
- Fucoidan protects against high-fat diet-induced obesity and modulates gut microbiota.
Osteoarthritis
In vitro study of the therapeutic potential of brown crude fucoidans in osteoarthritis treatment.
Osteoporosis
Oxidative stress
Prebiotic
- Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities.
- Fucoidan can be used as a gut microbiota modulator for health promotion and treatment of intestinal dysbiosis.
Pulmonary Fibrosis
Low molecular weight fucoidan attenuating pulmonary fibrosis.
Low molecular weight fucoidan inhibits pulmonary fibrosis.
Radiation Protection
- Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell survival and immunoreactivity.
- Suppressive Effect of Dietary Fucoidan on Proinflammatory Immune Response and MMP-1 Expression in UVB-Irradiated Mouse Skin
- Structural diversity of fucoidans and their radioprotective effect.
Renoprotective
- Oligo-fucoidan, fucoxanthin, and L-carnitine have a combined protective effect on the kidneys.
- Fucoidan-based micelles as P-selectin targeted carriers for synergistic treatment of acute kidney injury.
- Fucoidans from Cucumaria frondosa ameliorate renal interstitial fibrosis via inhibition of the PI3K/Akt/NF-κB signaling pathway.
Thyroid Effects
UVB Photodamage
Fucoidan isolated from Hizikia fusiforme suppresses ultraviolet B-induced photodamage.
Rheumatoid Arthritis
Wounds
Fucoidan promotes angiogenesis and accelerates wound healing.
Other Effects
- Fucoidan from Fucus vesiculosis Fails to Improve Outcomes Following Intracerebral Hemorrhage in Mice.
- Fucoidan attenuates hyperoxia-induced lung injury in newborn rats by mediating lung fibroblasts differentiate into myofibroblasts.
- Fucoidan supplementation restores fecal lysozyme concentrations in high-performance athletes.
- Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells.
- Fucoidan protects MSCs from ischemia-induced cell death by modulation of apoptosis-associated proteins and cellular ROS levels.
- Supplementation of elderly Japanese men and women with fucoidan from seaweed increases immune responses to **seasonal influenza vaccination**.
- Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury.
- Effect of fucoidan on ethanol-induced liver injury and steatosis in mice and the underlying mechanism.
- These results suggest that administration of fucoidan prevents the progression of osteoarthritis in a MIA-induced OA rats.
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