KOTMIN13

<a href="https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1155-4">Study:</a>
The ethanol extract of KOTMIN13, composed of <em class="EmphasisTypeItalic">Inula japonica</em> Flowers, <em class="EmphasisTypeItalic">Trichosanthes kirilowii</em> Semen, <em class="EmphasisTypeItalic">Peucedanum praeruptorum</em> Radix, and <em class="EmphasisTypeItalic">Allium macrostemon</em> Bulbs, was investigated for its anti-asthmatic and anti-allergic activities.
<div class="AbstractSection" id="ASec3">

                <h3 class="Heading">Results</h3>
                <p id="Par3" class="Para">In asthma model, KOTMIN13 

effectively suppressed airway hyperresponsiveness induced by aerosolized

methacholine when compared to the levels of OVA-induced mice. KOTMIN13

treatment reduced the total leukocytes, eosinophil percentage, and Th2

cytokines in the bronchoalveolar lavage fluids in OVA-induced mice. The

increased levels of eotaxin and Th2 cytokines in the lung as well as

serum IgE were decreased by KOTMIN13. The histological analysis shows

that the increased inflammatory cell infiltration and mucus secretion

were also reduced. In addition, the degranulation and leukotriene C₄ production were inhibited in BMMC with IC₅₀ values of 3.9&nbsp;μg/ml and 1.7&nbsp;μg/ml, respectively. Furthermore, KOTMIN13 treatment attenuated mast-mediated PCA reaction.</p>

              </div><div class="AbstractSection" id="ASec4">
                <h3 class="Heading">Conclusions</h3>
                <p id="Par4" class="Para">These results demonstrate that KOTMIN13 has anti-asthmatic and anti-allergic effects in vivo and in vitro models.</p>
              </div><br />