Cinnamon Studies

Note: Studies don't always indicate which species of Cinnamomum is used so this is a "general" list of studies that could apply to various cinnamons.

Dr SHIVA™ : Cinnamon on Digestive Health @CytoSolve® Systems Analysis (2/22)

This article presents a comprehensive analysis of the botanical, chemical, and pharmacological aspects of cinnamon.

The results indicate that the addition of the cinnamon extract significantly increased the antioxidant activity of the cocoa extract.

Acne

• The combination of cinnamon bark extract and honey has potential activity against acne-causing bacteria.

Cancer

• Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. .

Cardiovascular

• The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis. 
• Cinnamon polyphenol reduces the hyperlipidemia, inflammation, and oxidative stress.
• Cinnamon Helps Reduce High Blood Pressure
• The benefit of cinnamon in lowering total cholesterol levels after consumption of high-fat containing foods.

COVID-19

• Cinnamon May Help Protect You From Serious COVID-19 Complications, Study Says
• Benefits of Cinnamon in COVID-19: How it Fights Lung Infections And Boosts Immunity

Diabetes

• Changes in CYP2D enzyme activity following induction of type 2 diabetes, and administration of cinnamon and metformin: an experimental animal study.
• Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review. 
• Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial. 
• Cinnamon in diabetes mellitus. 
• From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark. 
• Cinnamon improves glucose and lipids of people with type 2 diabetes. 
• Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. 
• Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. 
• Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. 
• Efficacy of cinnamon as an adjuvant in reducing the glycemic biomarkers of type 2 diabetes mellitus.

Dysmenorrhea

• Cinnamon as compared significantly reduces the severity and duration of pain during menstruation, but this effect is less compared to that of Ibuprofen.

Episiotomy

Effects of cinnamon on perineal pain and healing of episiotomy: a randomized placebo-controlled trial.

Fasting Blood Glucose

Cinnamon intake lowers fasting blood glucose: meta-analysis. 

Gastrointestinal

Cinnamon water extract improves diarrhea symptoms by changing the gut environment.

Insulin Effects

• Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial. 
• A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. 

Liver Effects

Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. 

Metabolic Syndrome

Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome: a randomized double -blind control trial. 

Neuroprotective

• The neuroprotective effects of cinnamon associated with whole body improvement in insulin sensitivity and related changes in the brain.

Nitric Oxide

Inhibitory effect of 2’-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. 

Oral Health

Effect of Cinnamon Extract and Chlorhexidine Gluconate (0.2%) on the Clinical Level of Dental Plaque and Gingival Health: A 4-Week, Triple-Blind Randomized Controlled Trial. 

Overweight

• Cinnamon turns up the heat on fat cells

Urinary System

• Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects
• A compound in cinammon has anti-biofilm against uropathogenic Escherichia coli. -