Eleuthero Studies

• Variability in commercial ginseng products: an analysis of 25 preparations pf Acamtjp[amax semtocpsis review of botany, chemistry and pharmacology.
• Phytochemical content and pharma-nutrition study on Eleutherococcus senticosus fruits intractum.

Antiviral

Eleutherococcus senticosus root extract exhibits antiviral activity against rhinovirus, respiratory syncytial virus and influenza A virus in cell cultures.

Bone Health

The effects of Acanthopanax senticosus extract on bone turnover and bone mineral density in Korean postmenopausal women

Cancer

• Siberian ginseng extracts had antiproliferative activity on various cancer and normal cell lines.
• A. senticosus has potential to be developed as an effective anticancer treatment.
• Eleutherococcus amplifies the antiproliferative effects of chemotherapeutic agents in the treatment of leukemia.
• A. senticosus exhibited a potential for inhibition of histone deacetylase.
• Soluble polysaccharides from the root of Acanthopanax senticosus could inhibit proliferation and induce the apoptosis in HepG2 cells.

Diabetes

• Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats.
• Eleutheroside E, An Active Component of Eleutherococcus senticosus Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice

Exercise Performance

• Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance.
• The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human
• The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human.

Fatigue

• Bioactivity-guided fractionation for anti-fatigue property of Acanthopanax senticosus-
• Estimation of the combined effect of Eleutherococcus senticosus extract and cadmium on liver cells

Gastrointestinal Effects

Polysaccharides from Acanthopanax senticosus enhances intestinal integrity in lipopolysaccharide-challenged mice.

Hepatoprotective

• Eleutherococcus senticosus extract and cadmium on liver cells.
• Isofraxidin, a coumarin component from Acanthopanax senticosus inhibits matrix metalloproteinase-7 expression and cell invasion of human hepatoma cells.
• Effects of eleutheroside B and eleutheroside E on activity of cytochrome P450 in rat liver microsomes

Hormone Effects

Panax ginseng and Eleuthrococcus senticosus extracts—in vitro studies on binding to steroid receptors

Knee Osteoarthritis

• Effects of AIF on Knee Osteoarthritis Patients: Double-blind, Randomized Placebo-controlled Study.
• A water soluble extract of Panax notoginseng, Rehmannia glutinosa and Eleutherococcus senticosus is safe and effective for symptomatic improvement of pain and physical function in patients with knee osteoarthritis.

Immune System Effects

• Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage.
• Acanthopanax senticosus suppresses reactive oxygen species production by mouse peritoneal macrophages in vitro and in vivo
• The influence of active components of Eleutherococcus senticosus on cellular defense and physical fitness in man
• Inhibition of inducible nitric oxide synthase by Acanthopanax senticosus extract in RAW264.7 macrophages
• A comparative study on root and bark extracts of Eleutherococcus senticosus and their effects on human macrophages.

Metabolic Syndrome

Acanthopanax senticosus leaves could promote beneficial health effects including the prevention of metabolic syndrome.

Neuroprotective

• Active components from Siberian ginseng for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons. (
• Neuroprotective effects of Siberian ginseng bark on transient global cerebral ischemia in rats.
• Inhibitory effects of Elleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss.
• Eleutherococcus has a neuroprotective effect by inhibiting inflammation and microglial activation in brain ischemia.

Post-menopause

The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women

Quality of life in Elderly

Eleutherococcus improves the quality of life in the elderly.

Sleep Deprivation

• The effect of Eleutheroside E on behavioral alterations in murine sleep deprivation stress model.