CCL5 / RANTES
Wikipedia:
CCL5 is proinflammatory chemokine, recruiting leukocytesto the site of inflammation. It is chemotactic for T cells, eosinophils, and basophils, but also for monocytes, natural-killer (NK) cells, dendritic cells and mastocytes. With the help of particular cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, CCL5 also induces the proliferation and activation of certain NK cells to form CHAK (CC-Chemokine-activated killer) cells.It is also an HIV-suppressive factor released from CD8+ T cells.
The chemokine CCL5 is mainly expressed by T-cells and monocytes, and it has not been shown to be expressed by B-cells. Moreover, it is abundantly expressed by epithelial cells, fibroblasts and thrombocytes.
it has the highest affinity to the CCR5. CCR5 is presented on the surface of T-cells, smooth muscle endothelial cells, epithelial cells, parenchymal cells and other cell types.
CCL5 as a potential immunotherapeutic target in triple-negative breast cancer
Role of CCL5 (RANTES) in Viral Lung Disease
CCL5–Glutamate Cross-Talk in Astrocyte-Neuron Communication in Multiple Sclerosis