Rapamycin (TOR) Kinase

The target of rapamycin (TOR) kinase is a protein kinase that regulates cell growth. TOR is found in two complexes, TORC1 and TORC2, which are structurally and functionally distinct. These complexes act as regulatory hubs that link external signals to the cytoskeletal machinery in a variety of cell types and organisms.

TOR kinases are serine-threonine kinases that sense growth factor, nutrient, or oxygen status. They promote appropriate changes in cell growth and proliferation, cell survival, and protein synthesis.

TORC1 mainly regulates cell growth and metabolism, while TORC2 mainly controls cell proliferation and survival.

Too much mTOR has been linked to a shortened lifespan, cancers, and many chronic health conditions. Too little mTOR could cause other health issues such as liver problems, muscle atrophy, delayed healing, and disrupted insulin sensitivity.

Dietary protein increases TOR.