Berberine Studies
- Displacement of bilirubin from albumin by berberine.
- Berberine modulates GLP-1 via promoting GLP-1 secretion and GLP-1 biosynthesis.
- Polyphenols may have therapeutic value in a variety of diseases through modulating AMP-activated protein kinase which reduce fatty acid and cholesterol synthesis and gluconeogenesis.
- Berberine inhibits the ischemia-reperfusion induced testicular injury through decreasing oxidative stress.
- Berberine protects immortalized line of human melanocytes from H2O2-induced oxidative stress.
- The effects of Berberine in the treatment of type 2 diabetes, hyperlipidemia and hypertension
- Berberine: A multi-Target Natural PCSK9 Inhibitor with the potential to treat diabetes, Alzheimer's, cancer and cardiovascular disease.
ADVANCED GLYCATION END-PRODUCTS
ALLERGIC AIRWAY DISEASES
ALUMINUM TOXICITY
Alzheimer’s
- Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer's disease models.
- A review of the neuroprotective effects of berberine in animal models of Alzheimer's disease.
- Berberine reduces Aβ 42 deposition and tau hyperphosphorylation via ameliorating endoplasmic reticulum stress.
- Neuroprotective effects and possible mechanisms of berberine in animal models of Alzheimer's disease.
- Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance.
Antibacterial
ANTICONVULSIVE
Berberine has anticonvulsant activity in mice.
ANTIDEPRESSANT EFFECTS
- Study confirms antidepressant effects of berberine
- Berberine produces antidepressant-like effects in ovariectomized mice.
- Gut microbiota-SCFAs-brain axis associated with the antidepressant activity of berberine.
Anti-inflammatory
- Berberine may exert anti-inflammatory effects through multi-ingredients, multi-targets and multi-pathways.
- Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes.
- Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders.
- Berberine exerts therapeutic effects in inflammation-associated diseases.
- Anti-inflammatory potential of berberine-rich extract via modulation of inflammation biomarkers.
Antimicrobial
- Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor
- Barberry, Goldenseal, Oregan grape and Goldenthread contains berberine, a powerful antimicrobial.
- Berberine: A Medicinal Compound for the Treatment of Bacterial Infections
- Antibacterial activity and mechanism of berberine against *Streptococcus agalactiae*
- Antibacterial Mechanisms of Berberine and Reasons for Little Resistance of Bacteria*
- Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and vibrio cholerae
- Evaluation of berberine as an adjunct to TB treatment.
- Berberine derivatives as Pseudomonas aeruginosa MexXY-OprM inhibitors.
- Carvacrol enhances the antimicrobial potency of berberine in Bacillus subtilis.
- Effect of alkaloid berberine on the susceptibility of nontuberculous mycobacteria to antibiotics.
- Berberine at sub-inhibitory concentration inhibits biofilm dispersal in Staphylococcus aureus.
- The mechanism of berberine on methicillin resistant Staphylococcus aureus in vitro.
MULTI-DRUG RESISTANT PATHOGENS
MRSA
RSV
Berberine treatment suppresses the replication of Respiratory syncytial virus (RSV).
Antifungal
Antiviral
- Berberine hampers Influenza A replication through inhibition of MAPK/ERK pathway.
- Berberine impairs coxsackievirus B3-induced myocarditis through the inhibition of virus replication and host pro-inflammatory response.
- Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages.
- Berberine inhibits herpes simplex Virus 1 replication in HEK293T cells.
ARTHRITIS
- Berberine exerted a superior anti-arthritic effect and the mechanism maybe involve the balance between Treg and Th17 cells.
- Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages.
- Berberine attenuates arthritis in adjuvant-induced arthritis.
RHEUMATOID ARTHRITIS
- Berberine induces dendritic cell apoptosis and has therapeutic potential for rheumatoid arthritis.
- Berberine inhibits autophagy and promotes apoptosis of fibroblast-like synovial cells from rheumatoid arthritis patients.
AUTOIMMUNE Disorders
- Berberine attenuates experimental autoimmune encephalomyelitis in mice.
- Berberine attenuates experimental autoimmune myasthenia gravis via rebalancing the T cell subsets.
BPH
- An inhibitory effect of Berberine from herbal Coptis chinensis Franch on rat detrusor contraction in benign prostatic hyperplasia associated with lower urinary tract symptoms.
- Berberine ameliorates testosterone-induced benign prostate hyperplasia in rats.
BONE HEALTH
- Resveratrol, EGCG, berberine and alpha-lipoic acid may have a beneficial effect on bone health through negatively regulating RANKL.
- Berberine for bone regeneration: Therapeutic potential and molecular mechanisms.
Osteoporosis
Berberine alleviates oxidative stress in rats with osteoporosis.
Peronditis
Berberine suppresses bone loss and inflammation in ligature-induced periodontitis.
Post-Menopause Bone Health
BUBONIC PLAGUE
Berberine is a key component in Coptis chinensis with anti-plague activity.
Cancer
Candida
- Berberine achieves its anti-Candida activity by affecting the cell membrane.
- Synergistic effect of berberine hydrochloride and fluconazole against Candida albicans resistant isolates.
CARDIOVASCULAR
- A review of berberine in cardiovascular and metabolic diseases.
- Berberine prevents against myocardial injury induced by acute β-adrenergic overactivation.
- The ameliorative effect of berberine on vascular calcification by inhibiting endoplasmic reticulum stress.
- Berberine protects against simulated ischemia/reperfusion injury-induced H9C2 cardiomyocytes apoptosis.
- Berberine attenuates hypoxia-induced pulmonary arterial hypertension.
- Berberine may be a potential therapeutic agent for the treatment of patients with cardiac myocyte injury and ischemia.
- Mechanisms of berberine for the treatment of atherosclerosis based on network pharmacology.
- [Protective effects of berberine on spontaneous ventricular fibrillation in dogs after myocardial infarction
- Remodelling of gut microbiota by Berberine attenuates trimethylamine N-oxide-induced platelet hyperreaction and thrombus formation.
- The effective role of natural product berberine in modulating oxidative stress and inflammation related atherosclerosis.
- Berberine treats atherosclerosis via a vitamin-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.
- Berberine inhibits low shear stress-induced vascular endothelial inflammation.
- Berberine plays a cardioprotective in the myocardium of mice after myocardial infarction.
- The effects of berberine supplementation on cardiovascular risk factors in adults.
- Preventive effect of berberine on postoperative atrial fibrillation.
- Berberine decreases thrombosis potential induced by a high-choline diet.
- Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis.
HEART FAILURE
- A berberine derivative attenuates cardiac failure.
- Panax ginseng combined with berberine has a positive effect in experimental rats with chronic congestive heart failure.
- Berberine has cardiovascular effects which may benefit arrhythmias and/or heart failure.
High Cholesterol
- A combination of berberine, red yeast rice and policosanol lowers lipid levels and improves endothelial function and insulin sensitivity in hypercholesterolemic patients.
- Berberine, alone or with other nutraceuticals, can provide a modest positive impact on lipid concentrations.
- Berberine (a major constituent of goldenseal) has significant cholesterol-lowering action
- Berberine significantly promoted the excretion of cholesterol from the liver to the bile in hyperlipidemic hamsters, which decreased serum TC, TG and LDL-C levels.
- The medicinal plant goldenseal is a natural LDL-lowering agent with multiple bioactive components and new action mechanisms.
Pulmonary Arterial Hypertension
Berberine attenuates pulmonary arterial hypertension.
Cerebrovascular
- Berberine attenuates cerebral ischemia-reperfusion injury induced neuronal apoptosis.
- Anti-inflammatory efficacy of berberine nanomicelle for improvement of cerebral ischemia.
- Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion.
- Effect of berberine on the hippocampal structure, biochemical factors, memory, and blood-brain barrier in rat model of transient global cerebral ischemia.
Stroke
- Berberine exhibits neuroprotective qualities against ischemic brain damage in stroke models
- Berberine facilitates angiogenesis against ischemic stroke.
Cognitive Effects
- Berberine improves cognitive impairment by simultaneously impacting cerebral blood flow and β-amyloid accumulation.
- Berberine ameliorates cognitive disorder.
- Berberine ameliorates lipopolysaccharide-induced cognitive impairment.
- Berberine and hesperidin prevent the memory consolidation impairment.
- Berberine improves cognitive impairment by alleviating brain atrophy and promoting white matter reorganization.
Chikungunya
DEMENTIA
- Multi-target treatment of senile dementia by berberine is a potential avenue of study for senile dementia treatment.
- SOCS1 mediates berberine-induced amelioration of microglial activated states in N9 microglia exposed to β Amyloid.
- Research progress on antidepressant effects and mechanisms of berberine.
Diabetes
- Berberine slows the progression of prediabetes to diabetes.
- Berberine Supplement Shows Promise for Pre-Diabetes Management: New Study
- Sustained antidiabetic effects of a berberine-containing chinese herbal medicine through regulation of hepatic gene expression.
- Berberine promotes glucagon-like peptide-1 (7-36) amide secretion in streptozotocin-induced diabetic rats.
- This review investigates the renoprotective mechanisms of berberine in diabetic nephropathy and highlights the importance of berberine as a potential therapeutic treatment.
- Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis
- Berberine potentiates insulin secretion and prevents β-cell dysfunction through the miR-204/SIRT1 signaling pathway.
- Berberine improves the protective effects of metformin on diabetic nephropathy.
- Berberine regulates mesangial cell proliferation and cell cycle to attenuate diabetic nephropathy.
- The effect of berberine on metabolic profiles in type 2 diabetic patients.
- These data suggested that berberine alleviates diabetic renal tubulointerstitial injury.
- Berberine attenuates diabetic atherosclerosis.
- Protective effect of berberine in diabetic nephropathy.
- Berberine regulates GPX4 to inhibit ferroptosis of islet β cells.
- Berberine inhibits gluconeogenesis in spontaneous diabetic rats.
- Treatment of berberine alleviates diabetic nephropathy by reducing iron overload and inhibiting oxidative stress.
- Berberine blocks inflammasome activation and alleviates diabetic cardiomyopathy.
- Berberine Outshines Metformin for Diabetes
- Addressing the preventive and therapeutic perspective of berberine against diabetes.
- Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
TYPE 1 DIABETES
- Berberine prevents the progression of type 1 diabetes in mice through decreased Th17 and Th1 cytokine secretion.
- Berberine regulates GPX4 to inhibit ferroptosis of islet β cells.
Type 2 Diabetes
- Curcumin, berberine, catechin, quercetin and rutin had binding ability towards alpha-amylase and alpha-glucosidase.
- In this review, we systematically summarize the scientific evidence about BBR's antidiabetic mechanisms, its clinical effectiveness, and safety in the treatment of T2DM.
- Cinnamaldehyde and berberine have greater anti-diabetic efficacy than metformin.
- Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.
- Berberine has protective effect for diabetes through increasing insulin expression, beta cell regeneration, antioxidant enzyme activity and decreasing lipid peroxidation.
- Berberine protects mice against type 2 diabetes by promoting PPARγ-FGF21-GLUT2-regulated insulin sensitivity and glucose/lipid homeostasis.
DIARRHEA
Dyslipidemia
- Systematic review and meta-analysis on efficacy and safety of berberine for dyslipidemia
- Berberine improves glucose and lipid metabolism in HepG2 cells through AMPKα1 activation.
- Efficacy and safety of berberine for dyslipidaemias: a systematic review and meta-analysis of randomized clinical trials
- Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.
- Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver.
- Overall and sex-specific effect of berberine for the treatment of dyslipidemia in adults.
- Berberine ameliorates abnormal lipid metabolism.
- Berberine attenuates inflammation and oxidative stress and modulates lymphocyte E-NTPDase in acute hyperlipidemia.
DRUG & ALCOHOL INDUCED TOXICITY
- Berberine reduces thyroxine-induced diarrhea in rats.
- Coptidis rhizoma and Berberine inhibit the behavioral effects of cocaine.
- Coptidis Rhizoma attenuates repeated nicotine-induced behavioural sensitization in the rat.
- Treatment with berberine prevents the changes in oxidative stress and ChE activity, and consequently memory impairment in ethanol treated rats.
Epilepsy
- The present study demonstrated the anti-epileptogenic effect of berberine.
- Dry extracts of artichoke and berberine have beneficial effects in hypercholesterolemic patients.
- Impact of berberine on some epigenetic, transcription regulation and inflammatory biomarkers in a mice model of epilepsy.
Eyes
- Purinergic P2X7 receptor involves in anti-retinal photodamage effects of berberine.
- Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye.
Gastrointestinal Effects
- Berberine can be used as a regulator of the intestinal microbiome similar to the probiotics.
- Berberine: An inspiring resource for the treatment of colorectal diseases.
- Berberine alleviates dextran sodium sulfate-induced colitis.
- Protective effect of berberine against LPS-induced injury in the intestine.
- Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis.
- Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites.
- Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides.
- Berberine and its structural analogs have differing effects on functional profiles of individual gut microbiomes.
- Berberine inhibits IFN-γ signaling pathway in DSS-induced ulcerative colitis.
- Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders.
- Berberine inhibits dendritic cells differentiation in DSS-induced colitis by promoting Bacteroides fragilis.
- Berberine improves intestinal barrier function and reduces inflammation, immunosuppression, and oxidative stress.
- Berberine decreases intestinal GLUT2 translocation and reduces intestinal glucose absorption.
- Effects of berberine on gut microbiota in patients with mild metabolic disorders induced by olanzapine.
- Berberine increases stromal production of Wnt molecules and activates Lgr5+ stem cells to promote epithelial restitution in experimental colitis.
IBD
Berberine can ameliorate pro-inflammatory cytokines induced intestinal permeability in vitro,
Ulcerative Colitis
- iTRAQ-based pharmacoproteomics reveals potential targets of berberine, a promising therapy for ulcerative colitis.
- Berberine in the treatment of ulcerative colitis: A possible pathway through Tuft cells.
- Fingolimod in combination with berberine at reduced doses represents a novel therapy for ulcerative colitis.
- Pharmacological effects of berberine on models of ulcerative colitis.
- Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy.
- Berberine promotes M2 macrophage polarisation through the IL-4-STAT6 signalling pathway in ulcerative colitis treatment.
Gout
Hearing Loss
The effectiveness of berberine on noise-induced hearing loss.
Hepatoprotective
- The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease.
- Berberine improves liver injury induced glucose and lipid metabolic disorders.
- Berberine hydrochloride attenuates liver injury induced by acute hypoxic exposure.
- Methyltransferase SETD2 mediates hepatoprotection of berberine against steatosis.
- Berberine ameliorates non-alcoholic steatohepatitis in ApoE−/− mice
- Binding of berberine to PEBP1 synergizes with sorafenib to induce the ferroptosis of hepatic stellate cells.
- Berberine prevents NAFLD and HCC by modulating metabolic disorders.
- Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD.
Hyperglycemia
Berberine ameliorates glucocorticoid-induced hyperglycemia.
H. Pylori
Berberine containing quadruple therapy for initial *Helicobacter pylori* eradication
HIGH HOMOCYSTEINE
HIV
Berberine prevents HIV protease inhibitor-induced inflammation.
HPV
These natural inhibitors have been shown to block HPV infection and inhibition of HPV oncoproteins.
Hyperglycemia
- Berberine alleviates hyperglycemia by targeting hepatic glucokinase.
- The hypoglycemic effect of berberine and berberrubine involves modulation of intestinal FXR signalling pathway and inhibition of hepatic gluconeogenesis.
- Protective effect of berberine on high glucose and hypoxia-induced apoptosis.
- Changes of gut microbiota and metabolites are associated with berberine improving glucose and lipid metabolism disturbances.
Hyperuricemia
Berberine attenuates hyperuricemia by regulating urate transporters and gut microbiota.
Hypoglycemia
Immune System Effects
- Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo
- Berberine alleviates oxidized low-density lipoprotein-induced macrophage activation.
INSULIN SENSITIVITY/ RESISTANCE
- Berberine down-regulated myostatin rxpression and facilitated metabolism via smad pathway in insulin resistance.
- Berberine may overcome insulin resistance via modulating key molecules in insulin signaling pathway, leading to increased glucose uptake in insulin-resistant cells.
- These results suggest that berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokine profile in human preadipocytes and metabolic syndrome patients.
- Berberine can prevent fructose-induced insulin resistance in rats
- Berberine improves free-fatty-acid-induced insulin resistance.
- Berberine reduces insulin resistance through upregulation of insulin receptor expression.
- Berberine may be an effective therapeutic strategy for the treatment of obesity and insulin resistance.
- Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway.
- The combination of berberine and isoliquiritigenin synergistically improved adipose inflammation and obesity-induced insulin resistance.
Liver Effects
- Berberine inhibits hepatic stellate cell proliferation and prevents experimental liver fibrosis.
- Berberine alleviates non-alcoholic steatohepatitis through modulating gut microbiota mediated intestinal FXR activation.
- Molecular updates on berberine in liver diseases: Bench to bedside.
- Berberine protects against the hepatic damage induced by Paracetamol
- Repeated administration of berberine inhibits cytochromes P450 in humans.
- The therapeutic effects of berberine plus sitagliptin in a rat model of fatty liver disease.
- Berberine might attenuate the liver inflammatory response in the livers of rats with high-fat diet-induced NAFLD.
- Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury.
- Therapeutic potential of berberine in attenuating cholestatic liver injury.
Metabolic Syndrome / Metabolic Disorders
- The combined application of berberine in patients with metabolic syndrome can effectively regulate blood glucose and blood lipid of patients.
- Berberine relieves metabolic syndrome in mice.
- The effect of berberine supplementation on glycemic control and inflammatory biomarkers in metabolic disorders.
Mental Health
Berberine ameliorates depression-like behaviors.
Multiple Sclerosis
Berberine: A natural modulator of immune cells in multiple sclerosis.
Muscles
Neurological Effects
- Berberine alleviates amyloid β-induced mitochondrial dysfunction and synaptic loss.
- Berberine attenuates Aβ42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells.
- Berberine protects against neurological impairments and blood-brain barrier injury.
- Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPARδ for antioxidant action.
- Investigation of the effects of berberine on bortezomib-induced sciatic nerve and spinal cord damage.
- Berberine hydrochloride improves cognitive deficiency through hippocampal up-regulation of neurotrophins following inhalant self-administration of methamphetamine.
- Neuroprotective properties of berberine: molecular mechanisms and clinical implications.
- Neuroprotective potentials of berberine in rotenone-induced Parkinson's disease-like motor symptoms.
PERIPHERAL NERVE DISEASES
Obesity / Overweight
- These findings may provide novel mechanistic insight into the anti-obesity effects of berberine.
- Oral berberine ameliorates high-fat diet-induced obesity by activating TAS2Rs in tuft and endocrine cells in the gut.
- Prebiotic effect of berberine and curcumin Is associated with the improvement of obesity.
- Berberine attenuates the abnormal ectopic lipid deposition in skeletal muscle.
- This meta-analysis found a significant reduction of body weight, BMI, WC and CRP levels associated with berberine intake.
- Berberine inhibits adipogenesis in high-fat diet-induced obesity mice.
- Berberine and evodiamine inhibit human white preadipocyte differentiation, indicating their potential use as anti-obesity agents.
- Berberine exerts anti-adipogenic activity.
- Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of adipocyte.
- The effect of Berberine on weight loss in order to prevent obesity: A systematic review.
- The results of the current study support the use of berberine supplementation for the improvement of obesity indices.
- This study suggests that berberine is a potential weight loss and weight maintenance drug for patients with schizophrenia.
Pancreatitis
Berberine attenuates severity of chronic pancreatitis and fibrosis.
PCOS
- Berberine and puerarin lower the degree of insulin resistance and the androgen synthesis in procine ovarian thecal cells, indicating their potential value in the treatment of polycystic syndrome.
- Berberine plays a protective role in PCOS-IR, increasing insulin sensitivity, improving hyperandrogens and recovering abnormal blood lipids.
Peridontal Disease
- Berberine promotes osteogenic differentiation of mesenchymal stem cells with therapeutic potential in periodontal regeneration.
- Berberine accelerates odontoblast differentiation by Wnt/β-catenin activation.
Psoriasis
Berberine may serve as a potential therapeutic option for patients with psoriasis.
Renoprotective
- Berberine protects against fructose-and-salt induced hypertensive renal injury.
- Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota.
- Berberine attenuates uric acid-induced cell injury by inhibiting NLRP3 signaling pathway in HK-2 cells.
- Berberine alleviates ischemia reperfusion injury induced acute kidney injury.
Schizophrenia
Improvement of adjunctive berberine treatment on negative symptoms in patients with schizophrenia.
Sepsis
- Study on the protective effect of berberine treatment on sepsis based on gut microbiota and metabolomic analysis.
- Berberine is a potential therapeutic agent for sepsis.
- Ameliorating effects of berberine on sepsis-associated lung inflammation induced by lipopolysaccharide.
- Berberine protects against sepsis-related acute lung injury.
STRESS
Tuberculosis
Berberine governs NOTCH3/AKT signaling to enrich lung-resident memory T cells during tuberculosis.
Other Effects
- Effect of topical berberine in murine cutaneous leishmaniasis lesions.
- Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.
- Berberine ameliorates renal interstitial inflammation and fibrosis in mice with unilateral ureteral obstruction.
- Berberine alleviates cholesterol and bile acid metabolism disorders induced by high cholesterol diet.