Leukemia (pathophysiology)

Many studies have indicated a key role of STAT5a in leukemia

• Misregulated protein breakdown promotes leukemias and brain cancer
• Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.
• Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
• Leukemia Hijacks Glucose Metabolism By Inducing Insulin Resistance
• Leukemia-derived exosomes induced IL-8 production in bone marrow stromal cells to protect the leukemia cells against chemotherapy.