Witch Hazel, Studies

Conversion of phenolic constituents in aqueous Hamamelis virginiana leaf extracts during fermentation.

Many to flower, few to fruit: the reproductive biology of Hamamelis virginiana (Hamamelidaceae).

Anti-inflammatory

• Anti-inflammatory effect of hamamelis lotion in a UVB erythema test.
• Anti-inflammatory efficacy of topical preparations with 10% hamamelis distillate in a UV erythema test.

Antioxidant

• Evaluation of superoxide scavenging activities of hamamelis extract and hamamelitannin.
• Antioxidants in medicinal plant extracts. A research study of the antioxidant capacity of Crataegus, Hamamelis and Hydrastis.

Antiviral

• Tannins from Hamamelis virginiana bark extract: characterization and improvement of the antiviral efficacy against influenza A virus and human papillomavirus.
• Antiviral and antiphlogistic activities of Hamamelis virginiana bark.

Cancer

• Proanthocyanidins from the bark of Hamamelis virginiana exhibit antimutagenic properties against nitroaromatic compounds.
• Hamamelitannin from witch hazel (Hamamelis virginiana) displays specific cytotoxic activity against colon cancer cells.
• Witch hazel (Hamamelis virginiana) fractions and the importance of gallate moieties--electron transfer capacities in their antitumoral properties.
• Genotoxic and antigenotoxic effects of catechin and tannins from the bark of Hamamelis virginiana L. in metabolically competent, human hepatoma cells (Hep G2) using single cell gel electrophoresis.

Eczema

Comparative efficacy of hamamelis distillate and hydrocortisone cream in atopic eczema.

Hemorrhoids

[Drug therapy of hemorrhoids. Proven results of therapy with a hamamelis containing hemorrhoid ointment. Results of a meeting of experts. Dresden, 30 August 1991].

Oral Health

• Effectiveness of Oral Antiseptics on Tooth Biofilm: A Study in vivo.

Skin Effects

• Highly galloylated tannin fractions from witch hazel (Hamamelis virginiana) bark: electron transfer capacity, in vitro antioxidant activity, and effects on skin-related cells.
• Hamamelis in children with skin disorders and skin injuries: results of an observational study.
• Antiseptic effect of a topical dermatological formulation that contains Hamamelis distillate and urea.
• High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin.

Other Effects

• Dual inhibitory activities of tannins from Hamamelis virginiana and related polyphenols on 5-lipoxygenase and lyso-PAF: acetyl-CoA acetyltransferase.