Sweroside

Sweroside (or (- )- Sweroside) is a bioactive herbal ingredient isolated from Fructus Corni, which has been widely used for the treatment of osteoporosis in traditional Chinese medicine. Unfortunately, the working mechanisms of this compound are difficult to determine and thus remain unclear. Sweroside has shown anti-inflammatory and analgesic activities. Recently was found that sweroside attenuates α-naphthylisothiocyanate (ANIT)-induced cholestatic liver injury in mice by restoring bile acid synthesis and transport to their normal levels, as well as suppressing pro-inflammatory responses. Also has been suggested that sweroside can be a promising osteoporosis therapeutic natural product.  Source

ARTICLES/STUDIES

• Determination of sweroside in rat plasma and bile for oral bioavailability and hepatobiliary excretion
• Metabolism of sweroside from Swertia japonica by human intestinal bacteria
• Application of a liquid chromatography–tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of sweroside in rats

Anti-Aging

Anti-aging effects of sweroside isolated from Nymphoides indica

Anti-Inflammatory

• Sweroside alleviated LPS-induced inflammation via SIRT1 mediating NF-κB and FOXO1 signaling pathways in RAW264. 7 cells
• Protective Effects of Sweroside on IL-1β-Induced Inflammation in Rat Articular Chondrocytes Through Suppression of NF-κB and mTORC1 Signaling Pathway

Cancer

• Gentiopicroside and sweroside from Veratrilla baillonii Franch. induce phosphorylation of Akt and suppress Pck1 expression in hepatoma cells
• Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis.
• Antitumor effects of Sweroside in human glioblastoma: its effects on mitochondrial mediated apoptosis, activation of different caspases, G0/G1 cell cycle arrest

Cardiovascular

Sweroside alleviated aconitine-induced cardiac toxicity in H9c2 cardiomyoblast cell line

Hepatoprotective

• Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses
• Sweroside prevents non-alcoholic steatohepatitis by suppressing activation of the NLRP3 inflammasome
• Sweroside ameliorates NAFLD in high-fat diet induced obese mice through the regulation of lipid metabolism and inflammatory response
• Sweroside ameliorated carbon tetrachloride (CCl 4)-induced liver fibrosis through FXR-miR-29a signaling pathway

Osteoporosis

• Protective effects of sweroside on human MG-63 cells and rat osteoblasts
• Sweroside‐mediated mTORC1 hyperactivation in bone marrow mesenchymal stem cells promotes osteogenic differentiation

Other Effects

Modulation effects of sweroside isolated from the Lonicera japonica on melanin synthesis