Brucine

Brucine is a bitter, poisonous alkaloid that is closely related to strychnine. It is most commonly found in the Strychnos nux-vomica tree.

Toxicity

Brucine is highly toxic by ingestion and inhalation. It can cause paralysis of the peripheral nerve endings and produce violent convulsions.

Use

Brucine is used mainly in the denaturation of alcohol. It can also be used as a tool for stereospecific chemical syntheses.

Other information

• Brucine is also known as 10,11-Dimethoxystrychnine.
• Brucine poisoning is rare because it is usually ingested with strychnine, which is more toxic than brucine.
• In China, Nux-vomica has been used for centuries to treat ailments such as dyspepsia, nervous system diseases, and chronic rheumatism.

article/studies

Binding of brucine to human serum albumin

Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica

Cyp3a11 metabolism-based chronotoxicity of brucine in mice.

Antitumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma in vivo.

Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel.

Brucine inhibits TNF-alpha-induced HFLS-RA cell proliferation by activating the JNK signaling pathway.

Brucine lethality in mice

Cytotoxic and antitumor effects of brucine on Ehrlich ascites tumor and human cancer cell line

The Apoptotic Effect of Brucine from the Seed of *Strychnos nux-vomica* on Human Hepatoma Cells is Mediated via Bcl-2 and Ca^2+^ Involved Mitochondrial Pathway

The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC …

Brucine suppresses vasculogenic mimicry in human triple-negative breast cancer cell line MDA-MB-231

Fatal intoxication due to brucine

Anti-tumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma

Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo

The interaction of blood proteins with brucine

In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates

Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor …

Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel

Pharmacological characterisation of strychnine and brucine analogues at glycine and α7 nicotinic acetylcholine receptors

A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure

Brucine suppresses breast cancer metastasis via inhibiting epithelial mesenchymal transition and matrix metalloproteinases expressions

Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine

Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats

Antitumor effects of brucine immuno-nanoparticles on hepatocellular carcinoma in vivo

Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine

Brucine analysis for high nitrate concentrations