Clomifene / clomiphene
Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. Use results in a greater chance of twins. It is taken by mouth once a day, with a course of treatment that usually lasts for 5 days.
Common side effects include pelvic pain and hot flashes Other side effects can include changes in vision, vomiting, trouble sleeping, ovarian cancer, and seizures. It is not recommended in people with liver disease, abnormal vaginal bleeding of unknown cause, or who are pregnant. Clomifene is in the selective estrogen receptor modulator (SERM) family of medication and is a nonsteroidal medication. It works by causing the release of GnRH by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.
Popular Fertility Drug May Raise Miscarriage Risk Without Improving Live Birth Odds
High clomiphene doses increase risks. A widely used fertility drug may carry a hidden tradeoff: as treatment adds up, the risks may rise without improving the odds of a live birth. Researchers found that women exposed to higher cumulative doses of clomiphene citrate had progressively greater risks of miscarriage and multiple births, yet no corresponding improvement in the chance of [...]