Black Seed EO

Studies

Black Cumin CO2 - Organic, Egypt or India (see COA for lot specific origin), Eden Botanicals

Black cumin seed essential oil, as a potent analgesic and anti-inflammatory drug

High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.).

Cancer chemopreventive potential of volatile oil from black cumin seeds, Nigella sativa L., in a rat multi-organ carcinogenesis bioassay

Composition, in vitro antioxidant and antimicrobial activities of essential oil and oleoresins obtained from black cumin seeds (Nigella sativa L.)

Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models

Comparative analysis of essential oil composition of Iranian and Indian *Nigella sativa* L. extracted using supercritical fluid extraction and solvent extraction

Oral Nigella sativa oil safely reduces the osteoarthritis symptoms and analgesic dose in the knee osteoarthritis patients.

Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity.

Effect of Nigella sativa L. seed oil on urinary incontinence and quality of life in menopausal women.

Hydatid cyst

Surgery remains the preferred treatment for hydatid cyst (cystic echinococcosis, CE). Various scolicidal agents have been used for inactivation of protoscolices during surgery, but most of them are associated with adverse side effects. The present study aimed to evaluate the in vitro scolicidal effect of Nigella sativa (Ranunculaceae) essential oil and also its active principle, thymoquinone, against protoscolices of hydatid cysts. Protoscolices were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (0.01-10 mg/ml) and thymoquinone (0.125-1.0 mg/ml) were used for 5 to 60 min. Viability of protoscolices was confirmed by 0.1% eosin staining. Furthermore, the components of the N. sativa essential oil were identified by gas chromatography/mass spectroscopy (GC/MS). Our study revealed that the essential oil of N. sativa at the concentration of 10 mg/ml and its main component, thymoquinone, at the concentration of 1 mg/ml had potent scolicidal activities against protoscolices of Echinococcus granulosus after 10 min exposure. Moreover, thymoquinone (42.4%), p-cymene (14.1%), carvacrol (10.3%), and longifolene (6.1%) were found to be the major components of N. sativa essential oil by GC/MS analysis. The results of this study indicated the potential of N. sativa as a natural source for production of a new scolicidal agent for use in hydatid cyst surgery. However, further studies will be needed to confirm these results by checking the essential oil and its active component in in vivo models. Study

Thyroid Hormones

The positive effect of black seed (Nigella sativa L.) essential oil on thyroid hormones.