Bladderwrack, Studies
Antifungal
Antimicrobial
Cancer
- Molecular Mechanisms by Which a Fucus vesiculosus Extract Mediates Cell Cycle Inhibition and Cell Death in Pancreatic CancerCells.
- In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes.
- A *Fucus vesiculosus* extract inhibits estrogen receptor activation and induces cell death in female cancer cell lines
- Study Lactate dehydrogenase (LDH)-A is highly expressed in diverse human malignant tumors, parallel to aggressive metastatic disease, resistance to radiation/chemotherapy and clinically poor outcome. Although this enzyme constitutes a plausible target in treatment of advanced cancer, there are few known LDH-A inhibitors.
STUDY DESIGN:In this work, we utilized a high-throughput enzyme micro-array format to screen and evaluate > 900 commonly used medicinal plant extracts (0.00001-.5 mg/ml) for capacity to inhibit activity of recombinant full length human LDHA; EC .1.1.1.27.
METHODOLOGY:The protein sequence of purified enzyme was confirmed using 1D gel electrophoresis- MALDI-TOF-MS/MS, enzyme activity was validated by oxidation of NADH (500μM) and kinetic inhibition established in the presence of a known inhibitor (Oxalic Acid).
Results: Of the natural extracts tested, the lowest IC50s [Melaphis chinensis gallnut), Bladderwrack (Fucus vesiculosus), Kelp (Laminaria Japonica) and Babul (Acacia Arabica). Forty-six additional herbs contained significant LDH-A inhibitory properties with IC50s
Conclusion:These findings reflect relative potency by rank of commonly used herbs and plants that contain human LDH-A inhibitory properties. Future research will be required to isolate chemical constituents within these plants responsible for LDH-A inhibition and investigate potential therapeutic application.
Cardiovascular
The hypocholesterolemic potential of the edible algae Fucus vesiculosus.
Diabetes
Fucus vesiculosus polysaccharide alleviates type 2 diabetes.
Hepatoprotective
Hormones
- Consumption of bladderwrack results in an increase in the length of the menstrual cycle, and has significant anti-estrogenic and progestagenic effects.
- The effect of Fucus vesiculosus, an edible brown seaweed, upon menstrual cycle length and hormonal status in three pre-menopausal women: a case report.
- Brown kelp modulates endocrine hormones in female sprague-dawley rats and in human luteinized granulosa cells.
Metabolic Syndrome
Anti-metabolic syndrome effects of fucoidan from Fucus vesiculosus.