APOE Gene

The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. Lipoproteins are responsible for packaging cholesterol and other fats and carrying them through the bloodstream. Maintaining normal levels of cholesterol is essential for the prevention of disorders that affect the heart and blood vessels (cardiovascular diseases), including heart attack and stroke.

There are at least three slightly different versions (alleles) of the APOE gene. The major alleles are called e2, e3, and e4. The most common allele is e3, which is found in more than half of the general population.

Increasing understanding of the contributions made by the APO-E gene diet to better cardiovascular health was shared by Pamela McDonald, FNP, of Danville, California, showing societal patterns associated with promoting inflammation. Changes in farm/food reporting have resulted in inflated calorie statistics for companies to show greater profits, and drugs administered to cows to increase milk production have led to pathophysiology creating increases in breast cancer and other degenerative diseases. APO-E typing allows selection of proper dietary intake to "fuel the engine" with regard to fat and sugar management. APO-E 4's who get diabetes get Alzheimer's dementia, and their treatment has to be carefully managed for reversal. Similar resolution of peripheral ulcers can be obtained as well. APO-E 2/3, 3/3, or 3/4 must be monitored for adequate and proper food choices, especially aimed to reduce body fat and increase lean mass (BMI). In many respects, the APO-E molecule appears to fats what insulin is to sugars. Source

Study now links non-mutated Apolipoprotein E to dementia in the aging brain