Tocotrienols
TREATING MY TUMOR WITH TOCOTRIENOLS: A MEDICAL DOCTOR’S PERSONAL ACCOUNT
When taking tocotrienols as supplements, for maximum protection, you can't take them at the same time you're taking tocopherols because they can antagonize one another. Rice and Palm are 25-50% tocopherols, so don't take tocotrienol supplements with either.
Barrie Tan, PhD, of Hadley, Massachusetts, explained the cardiometabolic benefits of vitamin E tocotrienols, noting aside that studies are underway on other pathologies (obesity, cancer, fertility, neurodegenerative diseases). The "trienols" have taken a backseat to alpha-tocopherol, the marketed vitamin E discovered 100 years ago to help bring a fetus to term. Dietary intake is markedly deficient in meeting basic body need of about 250 mg daily. Ninety percent of antioxidants in cell membrane phospholipids are tocopherol – the remaining are mostly tocotrienols. Alpha-tocopherol-free supplementation is important to avoid antagonism and a reduced tocotrienol effect against inflammatory molecules, which interfere with protective benefit and tissue recovery from arteriosclerotic oxidative stress. Dr. Tan related that a hallmark observation from Stanford professor Gerald Reaven, MD, discoverer of metabolic syndrome: "Hypertriglyceridemia will always precede hyperglycemia," suggesting early supplementation might reduce emergence of pathology. Obesity and non-alcoholic liver steatosis result from disordered glucose/lipid metabolism. Tocotrienols have helped to reverse the associated inflammation and early fibrosis along with sponsoring weight loss. Infection (hepatitis C) and malignancy (liver and pancreatic cancer) appear to be advanced changes from metabolic syndrome.Source
ARTICLES/STUDIES
- Tocotrienol Research: Past to Present
- Tocotrienols supplement health benefit and side effects, daily dosage by Ray Sahelian, M.D.
- The 21st Century form of Vitamin E - Tocotrienol
- Tocotrienols: Vitamin E beyond tocopherols
- Characterization of Cellular Uptake and Distribution of Vitamin E
- Arterial compliance and vitamin E blood levels with a self emulsifying preparation of tocotrienol rich vitamin E
- Postprandial Levels of the Natural Vitamin E Tocotrienol in Human Circulation
- Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseases
- Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of α-tocopherol
Cancer
- Tocotrienols fight cancer by targeting multiple cell signaling pathways
- Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E
- Tocotrienols: Inflammation and Cancer
- Cytotoxicity and apoptotic activities of alpha-, gamma- and delta-tocotrienol isomers on human cancer cells
- Tocotrienols induce apoptosis in breast cancer cell lines via an endoplasmic reticulum stress-dependent increase in extrinsic death receptor signaling
- Multitargeted therapy of cancer by tocotrienols
Cardiovascular
- Tocotrienols and Cardiovascular Health
- Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation
Insulin Sensitivity
Neuroprotective
Tocotrienol: The Natural Vitamin E to Defend the Nervous System?
Urinary Tract
Oral tocotrienol treatment reduced the progression of urinary frequency and bladder fibrosis.