Licorice Root Studies
- Quantitative Analysis of Total Phenolic, Flavonoid Contents and HPTLC Fingerprinting for Standardization of Glycyrrhiza glabra Linn. Roots
- Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts.
- Glycyrrhiza glabra: a comprehensive review on its phytochemistry, biological activities, clinical evidence and toxicology.
- Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review
Anti-inflammatory
- Glycyrrhiza Glabra possibly exerts its anti-inflammatory effects by interfering with NF-kB/MAPKs crosstalk in LPS-activated macrophages.
- The anti-inflammatory activity of licorice, a widely used Chinese herb.
Antimicrobial
- Antimicrobial potential of Glycyrrhiza glabra roots.
- Effect of Aqueous and Alcoholic Licorice (Glycyrrhiza Glabra) Root Extract Against Streptococcus Mutans and Lactobacillus Acidophilus in Comparison to Chlorhexidine: An In Vitro Study
- Leaves Antimicrobial Activity of Glycyrrhiza glabra L.
- Antibacterial activity of Tribulus terrestris and its synergistic effect with Capsella bursa-pastoris and Glycyrrhiza glabra against oral pathogens: an in-vitro study
- Antibacterial activity of Glycyrrhiza glabra against oral pathogens: an in vitro study
Antiviral
- Antiviral effects of Glycyrrhiza species.
- Anti‐hepatitis C virus compounds obtained from *Glycyrrhiza uralensis* and other *Glycyrrhiza* species
- Water extract of Glycyrrhiza uralensis inhibited enterovirus 71 in a human foreskin fibroblast cell line
- The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb.
BPH
Burns
Impact of licorice root on the burn healing process.
Cancer
- Studies show: Licorice is a proven breast cancer fighter
- Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors.
- Hexane-ethanol extract of Glycyrrhiza uralensis containing licoricidin inhibits the metastatic capacity of DU145 human prostate cancer cells.
- Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell.
- Diprenylated flavonoids from licorice induce death of SW480 colorectal cancer cells.
- Recent advances in Glycyrrhiza glabra-containing herbs alleviating radiotherapy- and chemotherapy-induced adverse reactions.
- In-vitro antitumor activity of compounds from Glycyrrhiza glabra against C6 glioma cancer cells.
Candida
- Licorice contains compounds with antifungal activity against drug resistant forms of Candida albicans.
- Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans.
Cardiovascular
Atheroprotective effects of Glycyrrhiza glabra.
COVID-19
Detoxification
- Exploring the possible metabolism mediated interaction of Glycyrrhiza glabra extract with CYP3A4 and CYP2D6.
- Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts.
Diarrhea
Ethanol extract of Glycyrrhiza uralensis Fisch: antidiarrheal activity.
Gastrointestinal
- Glycyrrhiza polysaccharide alleviates dextran sulfate sodium-induced ulcerative colitis.
- The anti-inflammatory properties of licorice ( Glycyrrhiza glabra)-derived compounds in intestinal disorders.
- In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action.
- Licorice protects against ulcerative colitis via the Nrf2/PINK1-mediated mitochondrial autophagy.
Hepatoprotective
- Ethanol extract of licorice alleviates HFD-induced liver fat accumulation.
- Compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
- Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters in women with nonalcoholic fatty liver disease.
Hormone Effects
- Licorice reduces serum testosterone in healthy women.
- Licorice consumption and serum testosterone in healthy man
- Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo.
Licorice contains glycyrrhizin, which inhibits the enzyme in your body that breaks down cortisol. Inactivating this enzyme will help you gradually raise cortisol levels. It increases the half life of cortisol. Licorice is considered a very useful substance for boosting cortisol.
It works well with Reishi which lowers blood pressure, licorice can raise it. Put them together for balance.
A study published in the April 2003 issue of the “Journal of Molecular Neuroscience” found that several flavonoids, including glabrene, glabridin and 4'OmeG, a derivative of glabridin, inhibit serotonin reuptake. These plant chemicals act like the hormone estrogen, which is also a serotonin reuptake inhibitor. The authors suggest that licorice flavonoids may benefit pre and postmenopausal women with mild to moderate depression.
Hyperglycemia
Liquorice flavonoid oil suppresses hyperglycaemia.
Immunomodulatory
- Ethanol extract of Glycyrrhizae Radix modulates the responses of antigen-specific splenocytes in experimental autoimmune encephalomyelitis
- Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms
- Immunomodulatory and anticancer potential of Gan cao *(Glycyrrhiza uralensis* Fisch.) polysaccharides by CT-26 colon carcinoma cell growth inhibition and cytokine IL-7 upregulation in vitro
- History and the immunostimulatory effects of heat-processed licorice root products with or without honey.
- The immunomodulatory activities of licorice polysaccharides (Glycyrrhiza uralensis Fisch.) in CT 26 tumor-bearing mice
Liver Effects
- Hepatoprotective Effects of a Proprietary Glycyrrhizin Product during Alcohol Consumption: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study
- Hepatoprotective and Antioxidant Effects of Licorice Extract against CCl(4)-Induced Oxidative Damage in Rats
- Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents
- Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
MAO Inhibitor
- Neurological Effects
- Efficacy of whole extract of licorice in neurological improvement of patients after acute ischemic stroke
- Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ(25-35)-induced neurotoxicity in cultured rat cortical neurons.
Muscles
The effects of licorice flavonoid oil with respect to increasing muscle mass.
Neuroprotective
- Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's disease.
- Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus.
- Revisiting Licorice as a functional food in the management of neurological disorders.
Obesity
- Licorice flavonoid oil supplementation promotes a reduction of visceral fat in exercised rats.
- Licorice flavonoid oil exhibits anti-obesity action in diet-induced obesity in rats.
- Licorice suppresses abdominal fat accumulation and body weight gain in high-fat diet-induced obese mice
- A combination of Korean red ginseng extract and Glycyrrhiza glabra L. extract enhances their individual anti-obesity properties.
Oral Health
- Licorice lollipops showed a promising effect in reducing caries by decreasing Streptococcus mutans counts in the saliva.
- The antibacterial effect produced by ethanolic licorice root extract on S. mutans was comparable to chlorhexidine mouthwash.
Osteoporosis
Licorice extract may be a potential candidate for prevention of osteoporosis in menopausal women.
PCOS
The synergistic effect of Paeonia spp and Glycyrrhiza glabra on polycystic ovary induced in mice.
Respiratory Effects
- A randomized, double-blind comparison of licorice versus sugar-water gargle for prevention of postoperative sore throat and postextubation coughing.
- G.glabra may be suggested for the prevention and treatment of pulmonary fibrosis and inflammation.
Other Effects
Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products
A review of Glycyrrhiza glabra effects on metabolic syndrome.
Liquorice intake modulates ACE2 and HMGB1 levels in healthy individuals.
Effective licorice gargle juice for aphthous ulcer pain relief.