Glycitein

A new isoflavone glycoside in soybean seeds (Glycine max MERRILL), glycitein 7-O-β-D-(6"-O-acetyl) glucopyranoside

Synthesis of beta-maltooligosaccharides of glycitein and daidzein and their anti-oxidant and anti-allergic activities.

Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans.

Microbial transformation of bioactive compounds and production of ortho-dihydroxyisoflavones and glycitein from natural fermented soybean paste.

*In vitro* and *in vivo* metabolism of the soy isoflavone glycitein

Metabolism of glycitein (7, 4 '-dihydroxy-6-methoxy-isoflavone) by human gut microflora

Metabolism of the soy isoflavones daidzein, genistein and glycitein in human subjects.: Identification of new metabolites having an intact isoflavonoid skeleton

Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity

Effect of thermal processing on genistein, daidzein and glycitein content in soymilk

Formation of polyhydroxylated isoflavones from the soybean seed isoflavones daidzein and glycitein by bacteria isolated from tempe

Bones, effects

Glycitein effect on suppressing the proliferation and stimulating the differentiation of osteoblastic MC3T3-E1 cells. - Glycitein, as one of the three major isoflavones in soybeans, directly but significantly (about 50%) suppressed the proliferation of MC3T3-E1 and stimulated bone-related protein (alkaline phosphatase (ALP) and osteocalcin (OC)) expression. These results indicate that glycitein suppresses the proliferation of osteoblasts and promotes differentiation from its progenitor

Cancer

• Inhibitory effects of O-methylated isoflavone glycitein on human breast cancer SKBR-3 cells.
• Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression
• Lack of significant genotoxicity of purified soy isoflavones (genistein, daidzein, and glycitein) in 20 patients with prostate cancer
• Glycitein induces reactive oxygen species‐dependent apoptosis and G0/G1 cell cycle arrest through the MAPK/STAT3/NF‐κB pathway in human gastric cancer cells

Cerebrovascular

Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats

Estrogenic Effects

Estrogenic activity of glycitein, a soy isoflavone