Hyperproteic diet

<a href="http://www.omicsonline.org/proceedings/hyperproteic-diet-intestinal-microbiota-and-colonic-epithelium-the-dangerous-relationships-37909.html">Study:</a>
<h3 class="m-t-0 text-primary">Hyperproteic diet, intestinal microbiota and colonic epithelium: The dangerous relationships</h3><p>Abstract

        
        
          <br /></p><p>The protein consumption in countries like USA and France 

is largely above the recommended dietary intake and can represent

more than 4 times this value in slimming hyperproteic (HP) diet. This

results in increased transfer of undigested protein from

the small to the large intestine. We have shown in the rat model that HP

diet ingestion results in marked changes of the luminal

environment of the colonic epithelial cells with modifications of the

microbiota composition and its metabolic capacity. HP animals

had increased colonic water content and amino acid-derived bacterial

metabolites like ammonia, branched-chain fatty acids, ethanol,

organic acids, hydrogen sulfide etc. Several of those latter (ammonia,

hydrogen sulfide and p-cresol) are inhibitor of colonocyte

respiration when present in excess. In addition, p-cresol acts as a

genotoxic compound on colonocytes. Our recent results show that

HP diet consumption modifies the morphology of colonocytes and the

distribution of mucous cells in the colonic crypts. Lastly, by

using a transcriptomic approach, we noticed that the HP diet modifies in

colonocytes the expression of genes related to several cellular

functions including apoptosis, cellular architecture, adhesion, immunity

and DNA-damage-related events. Our team as part of a

European research project consortium has undertaken a study on the

effects of 3 weeks-HP diet ingestion in overweight volunteers.</p>